Peritumoral deposits as an adverse prognostic indicator of colorectal cancer

Abstract Background The aim of this study was to determine the prognostic value of peritumoral deposits (PTDs) in colorectal cancer (CRC). Methods A total of 695 patients with pT3/T4 CRC (1980 to 1999) were reviewed. Tumor deposits located ≥2 mm from the front of the direct spread in the primary tum...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of surgery 2014, Vol.207 (1), p.70-77
Main Authors: Ueno, Hideki, M.D., Ph.D, Hashiguchi, Yojiro, M.D., Ph.D, Shimazaki, Hideyuki, M.D., Ph.D, Shinto, Eiji, M.D., Ph.D, Kajiwara, Yoshiki, M.D., Ph.D, Nakanishi, Kuniaki, M.D., Ph.D, Kato, Kei, M.D., Ph.D, Maekawa, Kazuya, M.D, Nakamura, Takahiro, Ph.D, Yamamoto, Junji, M.D., Ph.D, Hase, Kazuo, M.D., Ph.D
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cancer therapies
Chemotherapy
Colon
Colorectal cancer
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Confidence intervals
Disease-Free Survival
Female
Growth pattern
Humans
Incidence
Invasive margin
Kaplan-Meier Estimate
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Patients
Peritumoral deposits
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk Factors
Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background The aim of this study was to determine the prognostic value of peritumoral deposits (PTDs) in colorectal cancer (CRC). Methods A total of 695 patients with pT3/T4 CRC (1980 to 1999) were reviewed. Tumor deposits located ≥2 mm from the front of the direct spread in the primary tumor were evaluated as PTDs. Results PTDs were observed in 111 patients (16.0%). The incidence of PTDs increased according to increasing N stage: 7% for N0, 22% for N1, and 39% for N2 ( P < .0001). Five-year disease-specific survival was 85.0% in patients without PTDs and 59.5% in those with PTDs ( P < .0001). Multivariate analysis showed that PTDs affected disease-specific survival independent of T and N stages. A significant prognostic impact of PTDs was similarly observed in another cohort comprising 474 patients with pT3/T4 CRC (2000 to 2005). The κ values among 8 observers were .70 for PTDs and .32 for the conventional growth pattern. Conclusions PTDs have considerable prognostic relevance and offer improved judgment reproducibility in assessing the invasive margin of CRC.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2013.04.009