Magnetic resonance elastography of liver in healthy asians: Normal liver stiffness quantification and reproducibility assessment

Purpose To determine normal liver stiffness values evaluated with magnetic resonance elastography (MRE) in healthy normal Asian volunteers and assess its reproducibility. Materials and Methods Liver stiffness was evaluated with MRE in 41 healthy Asians (23 females, 18 males; mean age, 41.8 years, an...

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Published in:Journal of magnetic resonance imaging 2014-01, Vol.39 (1), p.1-8
Main Authors: Venkatesh, Sudhakar K., Wang, Gang, Teo, Lynette L.S., Ang, Bertrand W.L.
Format: Article
Language:English
Subjects:
Adult
age
Asian Continental Ancestry Group
Body Mass Index
Elastic Modulus
Elasticity Imaging Techniques
Female
gender
Healthy Volunteers
Humans
Liver - pathology
liver stiffness measurement
magnetic resonance elastography
Magnetic resonance imaging
Male
Middle Aged
normal healthy subjects
Reference Values
reproducibility
Reproducibility of Results
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Summary:Purpose To determine normal liver stiffness values evaluated with magnetic resonance elastography (MRE) in healthy normal Asian volunteers and assess its reproducibility. Materials and Methods Liver stiffness was evaluated with MRE in 41 healthy Asians (23 females, 18 males; mean age, 41.8 years, and mean body mass index [BMI], 23.4 kg/m2) on a 1.5T clinical scanner. The correlations between mean liver stiffness and age, gender, BMI, and fat fraction percentage of the liver were studied. Another 12 volunteers underwent liver MRE exams on two separate days 4–6 weeks apart under similar conditions for reproducibility assessment. Intraclass correlation coefficient (ICC) analysis was performed and within‐subject coefficient of variation (CV) of stiffness was estimated. Results The mean ± standard deviation (SD) of liver stiffness in normal healthy Asian subjects was 2.09 ± 0.22 kPa (95% confidence interval [CI], 2.04–2.15 kPa; range 1.68–2.48 kPa). The mean liver stiffness did not significantly correlate with age, gender, BMI, or fat content of the liver. The ICC for mean liver stiffness was 0.90 (95% CI, 0.78–0.96) and CV ranged from 2.2%–11.4%. Conclusion The liver stiffness in normal Asians is not affected by age, gender, BMI, or fat content. Liver stiffness with MRE is highly reproducible. J. Magn. Reson. Imaging 2014;39:1–8. © 2013 Wiley Periodicals, Inc.
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.24084