ALS pathophysiology: Insights from the split-hand phenomenon

Highlights • Axonal dysfunction, as assessed by the axonal excitability technique, is a ubiquitous feature in amyotrophic lateral sclerosis (ALS) evident across the range of intrinsic hand muscle. • The split-hand phenomena is a specific clinical feature of ALS. • Axonal dysfunction may appear as a...

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Bibliographic Details
Published in:Clinical neurophysiology 2014-01, Vol.125 (1), p.186-193
Main Authors: Menon, Parvathi, Kiernan, Matthew C, Vucic, Steve
Format: Article
Language:English
Subjects:
Adult
Aged
ALS
Amyotrophic Lateral Sclerosis - complications
Amyotrophic Lateral Sclerosis - physiopathology
Axonal excitability
Axons - physiology
Female
Hand - innervation
Hand - physiopathology
Humans
Male
Middle Aged
Muscle, Skeletal - innervation
Muscle, Skeletal - physiopathology
Muscular Atrophy - etiology
Muscular Atrophy - physiopathology
Neurology
Split-hand
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Summary:Highlights • Axonal dysfunction, as assessed by the axonal excitability technique, is a ubiquitous feature in amyotrophic lateral sclerosis (ALS) evident across the range of intrinsic hand muscle. • The split-hand phenomena is a specific clinical feature of ALS. • Axonal dysfunction may appear as a downstream process that develops secondary to the intrinsic pathophysiological origins of ALS.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2013.07.022