MRI differentiation of low-grade from high-grade appendicular chondrosarcoma

Objectives To identify magnetic resonance imaging (MRI) features which differentiate low-grade chondral lesions (atypical cartilaginous tumours/grade 1 chondrosarcoma) from high-grade chondrosarcomas (grade 2, grade 3 and dedifferentiated chondrosarcoma) of the major long bones. Methods We identifie...

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Bibliographic Details
Published in:European radiology 2014-01, Vol.24 (1), p.232-240
Main Authors: Douis, Hassan, Singh, Leanne, Saifuddin, Asif
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Bone Neoplasms - diagnosis
Bones
Chondrosarcoma - diagnosis
Diagnosis, Differential
Diagnostic Radiology
Edema
Female
Femur - pathology
Follow-Up Studies
Humans
Humerus - pathology
Imaging
Internal Medicine
Interventional Radiology
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medicine
Medicine & Public Health
Middle Aged
Musculoskeletal
Neoplasm Staging - methods
Neuroradiology
Orthopedics
Patients
Radiology
Reproducibility of Results
Retrospective Studies
Scintigraphy
Surgery
Tibia - pathology
Tumors
Ultrasound
Young Adult
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Summary:Objectives To identify magnetic resonance imaging (MRI) features which differentiate low-grade chondral lesions (atypical cartilaginous tumours/grade 1 chondrosarcoma) from high-grade chondrosarcomas (grade 2, grade 3 and dedifferentiated chondrosarcoma) of the major long bones. Methods We identified all patients treated for central atypical cartilaginous tumours and central chondrosarcoma of major long bones (humerus, femur, tibia) over a 13-year period. The MRI studies were assessed for the following features: bone marrow oedema, soft tissue oedema, bone expansion, cortical thickening, cortical destruction, active periostitis, soft tissue mass and tumour length. The MRI-features were compared with the histopathological tumour grading using univariate, multivariate logistic regression and receiver operating characteristic curve (ROC) analyses. Results One hundred and seventy-nine tumours were included in this retrospective study. There were 28 atypical cartilaginous tumours, 79 grade 1 chondrosarcomas, 36 grade 2 chondrosarcomas, 13 grade 3 chondrosarcomas and 23 dedifferentiated chondrosarcomas. Multivariate analysis demonstrated that bone expansion ( P  = 0.001), active periostitis ( P  = 0.001), soft tissue mass ( P  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-013-3003-y