The biochemistry of the olfactory purinergic system

The olfactory system of the spiny lobster has purinergic receptors that are excited by the purine nucleotide, adenosine 5'-monophosphate (AMP). Both biochemical and physiological studies are in progress to characterize the purinergic receptor cells and the factors affecting their activity. Radi...

Full description

Saved in:
Bibliographic Details
Published in:Chemical senses 1986-01, Vol.11 (4), p.673-673
Main Authors: Trapido-Rosenthal, H G, Gleeson, R A, Carr, WES, Lambert, S M, Milstead, M L
Format: Article
Language:English
Subjects:
Marine
Panulirus argus
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The olfactory system of the spiny lobster has purinergic receptors that are excited by the purine nucleotide, adenosine 5'-monophosphate (AMP). Both biochemical and physiological studies are in progress to characterize the purinergic receptor cells and the factors affecting their activity. Radiolabeled substances have been used to discover that olfactory sensilla (aesthetasc sensilla) excised from the antennule of the lobster dephosporylate the olfactory stimulant AMP and internalize the dephosphorylated product, adenosine. These findings followed an earlier discovery that ( super(3)H)AMP, or some tritiated product of ( super(3)H)AMP, was rapidly internalized by a sensillar uptake system shown to be concentration dependent. Evidence that AMP is dephosphorylated prior to uptake was obtained with a double label experiment and by employing an inhibitor of 5'-nucleotidase.
ISSN:0379-864X