Protective effects of anti‐Bordetella pertussis adenylate cyclase antibodies against lethal respiratory infection of the mouse

Experimental respiratory infection of mice with a Bordetella pertussis clone producing and releasing high yields of pertussis toxin and adenylate cyclase was lethal, inducing complete edematous hemorrhagic alveolitis within 48–72 h. By preincubating the challenge inoculum with polyclonal antibodies...

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Bibliographic Details
Published in:FEMS microbiology letters 1987-06, Vol.42 (1), p.75-80
Main Authors: Brézin, Colette, Guiso, Nicole, Ladant, Daniel, Djavadi‐Ohaniance, Lisa, Megret, Françoise, Onyeocha, Ignatius, Alonso, Jean‐Michel
Format: Article
Language:English
Subjects:
Adenylate cyclase
Bacterial diseases
Biological and medical sciences
Bordetella pertussis
Experimental bacterial diseases and models
Hemorrhagic alveolitis
Infectious diseases
Medical sciences
Monoclonal antibody
Mouse
Passive protection
Pertussis toxin
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Summary:Experimental respiratory infection of mice with a Bordetella pertussis clone producing and releasing high yields of pertussis toxin and adenylate cyclase was lethal, inducing complete edematous hemorrhagic alveolitis within 48–72 h. By preincubating the challenge inoculum with polyclonal antibodies against the filamentous haemagglutinin (FHA), the pertussis toxin (Ptx), the adenylate cyclase (AC) or a monoclonal anti‐AC antibody, we found that only anti‐FHA and anti‐AC antibodies were protective against the lethal lesions. These results provide direct evidence that B. pertussis AC might be incriminated in the pathogenesis of whooping cough as a major toxin responsible for the local cytopathic syndrome in the respiratory tract.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.1987.tb02302.x