Effects of Low-Level Inhalation Exposure to Cyclosarin on Learned Behaviors in Sprague-Dawley Rats

The effects of low-level inhalation exposure to cyclosarin on learned behaviors in Sprague-Dawley rats are investigated. Sprague-Dawley rats are first trained on a variable-interval, 56-s (VI56) schedule of food reinforcement. The VI56 schedule specifies that a single level press, following an avera...

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Bibliographic Details
Published in:Journal of toxicology and environmental health. Part A 2006-01, Vol.69 (23), p.2167-2167
Main Authors: Genovese, Raymond F, Benton, Bernard J, Shippee, Sara J, Jakubowski, Edward M, Bonnell, Jessica C
Format: Article
Language:English
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Summary:The effects of low-level inhalation exposure to cyclosarin on learned behaviors in Sprague-Dawley rats are investigated. Sprague-Dawley rats are first trained on a variable-interval, 56-s (VI56) schedule of food reinforcement. The VI56 schedule specifies that a single level press, following an average interval of 56 s, produces food reinforcement. Subjects are then exposed to GF vapor at concentrations of 1.6-5.2 mg/m super(3), or air control, for 60 min. Following exposures, performance on the VI56 and acquisition and maintenance of a radial-arm maze (RAM) spatial memory task are evaluated during 55 test sessions over approximately 11 wk. GF exposures produce miosis in all subjects and other mild clinical signs of toxicity at the highest concentration. All subjects acquired, and maintained, performance on RAM task, and no significant differences are seen as a result of CF exposure.
ISSN:1528-7394