Effects of Low-Level Inhalation Exposure to Cyclosarin on Learned Behaviors in Sprague-Dawley Rats

The effects of low-level inhalation exposure to cyclosarin on learned behaviors in Sprague-Dawley rats are investigated. Sprague-Dawley rats are first trained on a variable-interval, 56-s (VI56) schedule of food reinforcement. The VI56 schedule specifies that a single level press, following an avera...

Full description

Saved in:
Bibliographic Details
Published in:Journal of toxicology and environmental health. Part A 2006-01, Vol.69 (23), p.2167-2167
Main Authors: Genovese, Raymond F, Benton, Bernard J, Shippee, Sara J, Jakubowski, Edward M, Bonnell, Jessica C
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 2167
container_issue 23
container_start_page 2167
container_title Journal of toxicology and environmental health. Part A
container_volume 69
creator Genovese, Raymond F
Benton, Bernard J
Shippee, Sara J
Jakubowski, Edward M
Bonnell, Jessica C
description The effects of low-level inhalation exposure to cyclosarin on learned behaviors in Sprague-Dawley rats are investigated. Sprague-Dawley rats are first trained on a variable-interval, 56-s (VI56) schedule of food reinforcement. The VI56 schedule specifies that a single level press, following an average interval of 56 s, produces food reinforcement. Subjects are then exposed to GF vapor at concentrations of 1.6-5.2 mg/m super(3), or air control, for 60 min. Following exposures, performance on the VI56 and acquisition and maintenance of a radial-arm maze (RAM) spatial memory task are evaluated during 55 test sessions over approximately 11 wk. GF exposures produce miosis in all subjects and other mild clinical signs of toxicity at the highest concentration. All subjects acquired, and maintained, performance on RAM task, and no significant differences are seen as a result of CF exposure.
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_14796235</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>14796235</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_147962353</originalsourceid><addsrcrecordid>eNqNirsOgkAQAK_QxOc_bGVHAoKirYjRhErtyYqLYs5bvD1Q_14LP8BqkpnpqH4wmy68OFxGPTUQufm-H8wXcV-d0rKkwglwCRk_vYxa0rAzV9ToKjaQvmqWxhI4huRdaBa0lYFvyQitoTOs6IptxVbg6w-1xUtD3hqfmt6wRycj1S1RC41_HKrJJj0mW6-2_GhIXH6vpCCt0RA3kgdRvJxPw1n49_gBkjVH1g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14796235</pqid></control><display><type>article</type><title>Effects of Low-Level Inhalation Exposure to Cyclosarin on Learned Behaviors in Sprague-Dawley Rats</title><source>Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Science and Technology Collection (Reading list)</source><creator>Genovese, Raymond F ; Benton, Bernard J ; Shippee, Sara J ; Jakubowski, Edward M ; Bonnell, Jessica C</creator><creatorcontrib>Genovese, Raymond F ; Benton, Bernard J ; Shippee, Sara J ; Jakubowski, Edward M ; Bonnell, Jessica C</creatorcontrib><description>The effects of low-level inhalation exposure to cyclosarin on learned behaviors in Sprague-Dawley rats are investigated. Sprague-Dawley rats are first trained on a variable-interval, 56-s (VI56) schedule of food reinforcement. The VI56 schedule specifies that a single level press, following an average interval of 56 s, produces food reinforcement. Subjects are then exposed to GF vapor at concentrations of 1.6-5.2 mg/m super(3), or air control, for 60 min. Following exposures, performance on the VI56 and acquisition and maintenance of a radial-arm maze (RAM) spatial memory task are evaluated during 55 test sessions over approximately 11 wk. GF exposures produce miosis in all subjects and other mild clinical signs of toxicity at the highest concentration. All subjects acquired, and maintained, performance on RAM task, and no significant differences are seen as a result of CF exposure.</description><identifier>ISSN: 1528-7394</identifier><language>eng</language><ispartof>Journal of toxicology and environmental health. Part A, 2006-01, Vol.69 (23), p.2167-2167</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Genovese, Raymond F</creatorcontrib><creatorcontrib>Benton, Bernard J</creatorcontrib><creatorcontrib>Shippee, Sara J</creatorcontrib><creatorcontrib>Jakubowski, Edward M</creatorcontrib><creatorcontrib>Bonnell, Jessica C</creatorcontrib><title>Effects of Low-Level Inhalation Exposure to Cyclosarin on Learned Behaviors in Sprague-Dawley Rats</title><title>Journal of toxicology and environmental health. Part A</title><description>The effects of low-level inhalation exposure to cyclosarin on learned behaviors in Sprague-Dawley rats are investigated. Sprague-Dawley rats are first trained on a variable-interval, 56-s (VI56) schedule of food reinforcement. The VI56 schedule specifies that a single level press, following an average interval of 56 s, produces food reinforcement. Subjects are then exposed to GF vapor at concentrations of 1.6-5.2 mg/m super(3), or air control, for 60 min. Following exposures, performance on the VI56 and acquisition and maintenance of a radial-arm maze (RAM) spatial memory task are evaluated during 55 test sessions over approximately 11 wk. GF exposures produce miosis in all subjects and other mild clinical signs of toxicity at the highest concentration. All subjects acquired, and maintained, performance on RAM task, and no significant differences are seen as a result of CF exposure.</description><issn>1528-7394</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqNirsOgkAQAK_QxOc_bGVHAoKirYjRhErtyYqLYs5bvD1Q_14LP8BqkpnpqH4wmy68OFxGPTUQufm-H8wXcV-d0rKkwglwCRk_vYxa0rAzV9ToKjaQvmqWxhI4huRdaBa0lYFvyQitoTOs6IptxVbg6w-1xUtD3hqfmt6wRycj1S1RC41_HKrJJj0mW6-2_GhIXH6vpCCt0RA3kgdRvJxPw1n49_gBkjVH1g</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Genovese, Raymond F</creator><creator>Benton, Bernard J</creator><creator>Shippee, Sara J</creator><creator>Jakubowski, Edward M</creator><creator>Bonnell, Jessica C</creator><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>20060101</creationdate><title>Effects of Low-Level Inhalation Exposure to Cyclosarin on Learned Behaviors in Sprague-Dawley Rats</title><author>Genovese, Raymond F ; Benton, Bernard J ; Shippee, Sara J ; Jakubowski, Edward M ; Bonnell, Jessica C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_147962353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Genovese, Raymond F</creatorcontrib><creatorcontrib>Benton, Bernard J</creatorcontrib><creatorcontrib>Shippee, Sara J</creatorcontrib><creatorcontrib>Jakubowski, Edward M</creatorcontrib><creatorcontrib>Bonnell, Jessica C</creatorcontrib><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Journal of toxicology and environmental health. Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Genovese, Raymond F</au><au>Benton, Bernard J</au><au>Shippee, Sara J</au><au>Jakubowski, Edward M</au><au>Bonnell, Jessica C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Low-Level Inhalation Exposure to Cyclosarin on Learned Behaviors in Sprague-Dawley Rats</atitle><jtitle>Journal of toxicology and environmental health. Part A</jtitle><date>2006-01-01</date><risdate>2006</risdate><volume>69</volume><issue>23</issue><spage>2167</spage><epage>2167</epage><pages>2167-2167</pages><issn>1528-7394</issn><abstract>The effects of low-level inhalation exposure to cyclosarin on learned behaviors in Sprague-Dawley rats are investigated. Sprague-Dawley rats are first trained on a variable-interval, 56-s (VI56) schedule of food reinforcement. The VI56 schedule specifies that a single level press, following an average interval of 56 s, produces food reinforcement. Subjects are then exposed to GF vapor at concentrations of 1.6-5.2 mg/m super(3), or air control, for 60 min. Following exposures, performance on the VI56 and acquisition and maintenance of a radial-arm maze (RAM) spatial memory task are evaluated during 55 test sessions over approximately 11 wk. GF exposures produce miosis in all subjects and other mild clinical signs of toxicity at the highest concentration. All subjects acquired, and maintained, performance on RAM task, and no significant differences are seen as a result of CF exposure.</abstract></addata></record>
fulltext fulltext
identifier ISSN: 1528-7394
ispartof Journal of toxicology and environmental health. Part A, 2006-01, Vol.69 (23), p.2167-2167
issn 1528-7394
language eng
recordid cdi_proquest_miscellaneous_14796235
source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Science and Technology Collection (Reading list)
title Effects of Low-Level Inhalation Exposure to Cyclosarin on Learned Behaviors in Sprague-Dawley Rats
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T22%3A34%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Low-Level%20Inhalation%20Exposure%20to%20Cyclosarin%20on%20Learned%20Behaviors%20in%20Sprague-Dawley%20Rats&rft.jtitle=Journal%20of%20toxicology%20and%20environmental%20health.%20Part%20A&rft.au=Genovese,%20Raymond%20F&rft.date=2006-01-01&rft.volume=69&rft.issue=23&rft.spage=2167&rft.epage=2167&rft.pages=2167-2167&rft.issn=1528-7394&rft_id=info:doi/&rft_dat=%3Cproquest%3E14796235%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_miscellaneous_147962353%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=14796235&rft_id=info:pmid/&rfr_iscdi=true