Effects of Chronic Cs-137 Ingestion on Barrier Properties of Jejunal Epithelium in Rats

Effects of chronic super(137)Cs ingestion on barrier properties of jejunal epithelium in rats were examined. The animals received 150 Bq per day in drinking water over 3 mo. Epithelial integrity was maintained following the chronic ingestion of super(137)Cs, as demonstrated by histological analyses...

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Bibliographic Details
Published in:Journal of toxicology and environmental health. Part A 2007-05, Vol.70 (9), p.810-810
Main Authors: Dublineau, I, Grison, S, Grandcolas, L, Baudelin, C, Paquet, F, Viosin, P, Aigueperse, J
Format: Article
Language:English
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Summary:Effects of chronic super(137)Cs ingestion on barrier properties of jejunal epithelium in rats were examined. The animals received 150 Bq per day in drinking water over 3 mo. Epithelial integrity was maintained following the chronic ingestion of super(137)Cs, as demonstrated by histological analyses and electrical transepithelial parameters. Cesium contamination seemed to induce contradictory effects on the apoptosis pathway, with an increase in the gene expression of Fas/FasL and a decrease in the apoptotic cell number present in intestinal mucosa. The results showed that chronic ingestion of [137Cs] over 3 mo at postaccidental doses exerted few biological effects on the epithelium of rat jejunum with regard to morphology, inflammation status, apoptosis/proliferation processes, and secretory functions.
ISSN:1528-7394
DOI:10.1080/15287390701209113