Effect of Whole-Body VX Vapor Exposure on Lethality in Rats

Effects of whole-body O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothiolate (VX) vapor exposure on lethality in rats are investigated. Estimated exposure dosages producing lethal effects in 50% of exposed male and female rats are established for 10, 60, and 240 min exposure durations. A pote...

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Bibliographic Details
Published in:Inhalation toxicology 2006-01, Vol.18 (11), p.1091-1091
Main Authors: Benton, B J, McGuire, J M, Sommerville, DR, Dabisch, P A, Jakubowski, E M, Matson, K L, Mioduszewski, R J
Format: Article
Language:English
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Summary:Effects of whole-body O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothiolate (VX) vapor exposure on lethality in rats are investigated. Estimated exposure dosages producing lethal effects in 50% of exposed male and female rats are established for 10, 60, and 240 min exposure durations. A potency comparison with sarin (GB) and cyclosarin (GF) shows that VX becomes increasingly more potent than these G agents with increasing exposure duration. VX is approximately 4-30 times more potent than GB and 5-15 times more potent than GF. An empirical toxic load model is developed and the toxic load exponent for lethality in the equation C super(n) T = k is determined to be n = 0.92. The VX-G regeneration assay is successfully used as a biomarker for the presence of VX in the blood plasma and RBC fractions of the blood 24 h postexposure.
ISSN:0895-8378