Recovery from ultraviolet light-induced inhibition of DNA synthesis requires umuDC gene products in recA718 mutant strains but not in recA super(+) strains of Escherichia coli

Ultraviolet light (UV) inhibits DNA replication in Escherichia coli and induces the SOS response, a set of survival-enhancing phenotypes due to derepression of DNA damage-inducible genes, including recA and umuDC . The authors discuss the results in relation to the essential, but unidentified, roles...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1987-01, Vol.84 (19), p.6805-6809
Main Authors: Witkin, E M, Roegner-Maniscalco, V, Sweasy, J B, McCall, JO
Format: Article
Language:English
Subjects:
Escherichia coli
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Summary:Ultraviolet light (UV) inhibits DNA replication in Escherichia coli and induces the SOS response, a set of survival-enhancing phenotypes due to derepression of DNA damage-inducible genes, including recA and umuDC . The authors discuss the results in relation to the essential, but unidentified, roles of RecA and UmuDC proteins in UV mutagenesis.
ISSN:0027-8424