Metabolite Profiling of [ super(14)C]Hexahydro-1, 3, 5-Trinitro-1,3,5-Triazine (RDX) in Yucatan Miniature Pigs

Various issues related to metabolite profiling of [ super(14)C] hexahydro-1, 3, 5-trinitro-1, 3, 5-triazine (RDX) in Yucatan miniature pigs were discussed. Blood, plasma, liver and excreta were analyzed for total RDX-derived radioactivity and metabolites were identified. Analysis by a more sensitive...

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Published in:Journal of toxicology and environmental health. Part A 2007-01, Vol.70 (13), p.1191-1191
Main Authors: Major, Michael A, Reddy, Gunda, Berge, Milan A, Patzer, Shari S, Li, Austin C, Gohdes, Mark
Format: Article
Language:English
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Summary:Various issues related to metabolite profiling of [ super(14)C] hexahydro-1, 3, 5-trinitro-1, 3, 5-triazine (RDX) in Yucatan miniature pigs were discussed. Blood, plasma, liver and excreta were analyzed for total RDX-derived radioactivity and metabolites were identified. Analysis by a more sensitive method (LC/MS/MS) also showed trace amounts of the RDX metabolites 1-nitroso-3, 5-dinitro-1, 3, 5-triazacyclohexane (MX) and 1-nitro-3, 5-dinitroso-1, 3, 5-dinitroso-1, 3, 5-triazacycloheane (DNX). None of the liver extracts showed quantifiable levels of RDX or any identifiable metabolites. Most of the radioactivity was in the form of water-soluble high-molecular weight compounds. RDX when given orally to pigs was rapidly metabolized by loss of two nitro groups followed by ring cleavage.
ISSN:1528-7394