Stiffness Alternations of Single Cells Induces by UV in the Presence of NanoTiO sub(2)

Changes in mechanical properties of human skin fibroblasts, exposed to the oxidative stress induced in the presence of nanocrystalline titanium dioxide (nanoTiO sub(2)) and ultraviolet (UV) light, were studied. Atomic force microscopy (AFM) measurements of the cell stiffness were carried out immedia...

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Bibliographic Details
Published in:Environmental science & technology 2007-07, Vol.41 (14), p.5149-5149
Main Authors: Vileno, Bertrand, Lekka, Malgorzata, Sienkiewicz, Andrzej, Jeney, Sylvia, Stoessel, Gabriela, Lekki, Janusz, ro, Laszlo
Format: Article
Language:English
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Summary:Changes in mechanical properties of human skin fibroblasts, exposed to the oxidative stress induced in the presence of nanocrystalline titanium dioxide (nanoTiO sub(2)) and ultraviolet (UV) light, were studied. Atomic force microscopy (AFM) measurements of the cell stiffness were carried out immediately after exposure of cells to the oxidative stress. The results highlighted the sensitivity of AFM to detect early changes in mechanical properties of cells exposed to oxidative stress. The results suggested that the effect of UVC was so dominant that it was not possible to separate it from the effect of reactive oxygen species (ROS) on living cells after UVC illumination in the presence of TiO sub(2) nanoparticles. The results concluded that the early changes in cellular stiffness were more likely caused by the UVC radiation itself.
ISSN:0013-936X