Approaches to Acrylamide Physiologically Based Toxicokinetic Modeling for Exploring Child-Adult Dosimetry Differences

Potential impact of inter-individual variability in metabolic parameters on dosimetry results using Monte Carlo analysis is evaluated. The results provide a plausible range for child/adult dosimetry differences while addressing uncertainties in glutathione transferase (GST/GSH) detoxification pathwa...

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Bibliographic Details
Published in:Journal of toxicology and environmental health. Part A 2007-01, Vol.70 (23), p.2033-2033
Main Authors: Walker, Katherine, Hattis, Dale, Russ, Abel, Sonawane, Bob, Ginsberg, Gary
Format: Article
Language:English
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Summary:Potential impact of inter-individual variability in metabolic parameters on dosimetry results using Monte Carlo analysis is evaluated. The results provide a plausible range for child/adult dosimetry differences while addressing uncertainties in glutathione transferase (GST/GSH) detoxification pathway using alternative modeling assumptions. Consideration of children's dosimetry may be especially important with respect to glycinamide area under the curve (AUC) and cancer risk assessment. The estimated elevations in glycinamide AUC may lead to increased tissue macromolecular binding in children. Recent evaluations use hemoglobin adducts and urinary biomarkers to assess population exposures to acrylamide and glycinamide. It is concluded that acrylamide and glycinamide mode of action will help clarify the role of various dose metrics in predicting internal exposure and risk.
ISSN:1528-7394