Effects of acute and chronic treatment with imipramine on 5-hydroxytryptamine nerve cell groups and on bulbospinal 5-hydroxytryptamine/substance P/thyrotropin releasing hormone immunoreactive neurons in the rat. A morphometric and microdensitometric analysis

Groups of male rats were treated for a period of 14 days with imipramine given twice daily. 5-hydroxytryptamine (5-HT)-, substance P (SP)- and thyrotropin releasing hormone (TRH)-like immunoreactivities (IRs) were visualized in consecutive coronal sections of the brain stem and of the spinal cord. I...

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Published in:Journal of Neural Transmission 1987-01, Vol.70 (3-4), p.251-285
Main Authors: KITAYAMA, I, JANSON, A. M, STEINBUSCH, H. W. M, VISSER, T. J, FUXE, K, AGNATI, L. F, CINTRA, A, OGREN, S. O, HARFSTRAND, A, ENERITH, P, TSUTSUMI, T, JONSSON, G
Format: Article
Language:English
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Applied sciences
Biological and medical sciences
Exact sciences and technology
Medical sciences
Neuropharmacology
Other techniques and industries
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
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Summary:Groups of male rats were treated for a period of 14 days with imipramine given twice daily. 5-hydroxytryptamine (5-HT)-, substance P (SP)- and thyrotropin releasing hormone (TRH)-like immunoreactivities (IRs) were visualized in consecutive coronal sections of the brain stem and of the spinal cord. It is suggested that chronic imipramine treatment specifically increases SPIR in the 5-HT/SP/TRH costoring nerve terminals of the ventral horn probably related to reduced SP release and reduced 5-HT utilization in these terminals.
ISSN:0300-9564
1435-1463
DOI:10.1007/BF01253602