Stimulation of Inositol Phosphate Release in Intact and Permeabilized Fibroblasts

Studies in the authors' laboratory are centered on determining how a quiescent cell is stimulated to undergo mitosis. Their work has concentrated on the early responses of cells to mitogenic stimuli under the presumption that these events prime the cells for the subsequent synthetic events requ...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1987, Vol.494 (1), p.123-125
Main Authors: JAMIESON JR, GORDON A., VILLEREAL, MITCHEL L.
Format: Article
Language:English
Subjects:
fibroblasts
inositol phosphates
man
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Summary:Studies in the authors' laboratory are centered on determining how a quiescent cell is stimulated to undergo mitosis. Their work has concentrated on the early responses of cells to mitogenic stimuli under the presumption that these events prime the cells for the subsequent synthetic events required before cell division can occur. Specifically they are interested in understanding in detail the mechanism by which stimulation of quiescent human fibroblasts with mitogens leads to the rapid calcium-dependent stimulation of Na influx via the activation of an amiloride-sensitive Na-H exchanger present in the membranes of cells.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1987.tb29499.x