Pathogenesis and treatment of acute hematogenous osteomyelitis: Evaluation of current views with reference to an animal model

Antibiotic therapy and surgical drainage of the bone are the most commonly accepted forms of therapy for acute hematogenous osteomyelitis; the efficacy of these two treatment modalities, however, has not been fully established. Treatment regimens remain empiric and open to much controversy. Many con...

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Bibliographic Details
Published in:The Journal of infectious diseases 1986-01, Vol.8 (6), p.841-849
Main Authors: Emslie, K R, Nade, S
Format: Article
Language:English
Online Access:Get full text
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Summary:Antibiotic therapy and surgical drainage of the bone are the most commonly accepted forms of therapy for acute hematogenous osteomyelitis; the efficacy of these two treatment modalities, however, has not been fully established. Treatment regimens remain empiric and open to much controversy. Many contentious issues concerning the management of this disease have arisen (1) because the natural history of the untreated condition has not been properly understood, (2) because therapeutic regimens alternative to those empirically initiated and perpetuated have not been adequately tested, and (3) because most follow-up studies have dealt with small numbers of patients over relatively short periods. A highly reproducible animal model of acute hematogenous osteomyelitis was developed and utilized in a reexamination of issues regarding the natural history and pathology of disease and the influence of appropriate treatment.
ISSN:0022-1899