Injury of Catecholaminergic Neurons after Acute Exposure to MPTP: A TH Immunocytochemical Study in Monkey

Recent studies have shown that acute exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces severe parkinsonian symptoms in both man and monkey. Neuropathological examinations of parkinsonian brains in these studies revealed marked cell loss in the substantia nigra pars compacta. T...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1987, Vol.495 (1), p.730-731
Main Authors: KITT, CHERYL A., CORK, LINDA C., EIDELBERG, EDUARDO, JOH, TONG H., PRICE, DONALD L.
Format: Article
Language:English
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Summary:Recent studies have shown that acute exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces severe parkinsonian symptoms in both man and monkey. Neuropathological examinations of parkinsonian brains in these studies revealed marked cell loss in the substantia nigra pars compacta. The present study employed immunocytochemical methods to assess structural changes in catecholaminergic systems after acute MPTP exposure in nonhuman primates.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1987.tb23724.x