Anti-class II antibodies in AIDS patient and AIDS-risk groups

The specificity of anti-lymphocyte antibodies was evaluated in AIDS patients and in individuals at risk of AIDS (R-AIDS: male homosexuals (Ho) and haemophiliacs (He)). Antibodies capable of inducing antibody-dependent cell-mediated cytotoxicity (ADCC) against non-T cells and lymphoblastoid cell line...

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Bibliographic Details
Published in:Immunology 1987-01, Vol.62 (4), p.599-604
Main Authors: De La Barrera, S, Fainboim, L, Lugo, S, Picchio, G R, Muchinik, G R, De Bracco, MME
Format: Article
Language:English
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Summary:The specificity of anti-lymphocyte antibodies was evaluated in AIDS patients and in individuals at risk of AIDS (R-AIDS: male homosexuals (Ho) and haemophiliacs (He)). Antibodies capable of inducing antibody-dependent cell-mediated cytotoxicity (ADCC) against non-T cells and lymphoblastoid cell lines (P3HR-1K and Raji) were detected in AIDS patients and in R-AIDS with positive or negative human immune deficiency virus (HIV) serology. Anti-class II antigen specificity was revealed by experiments in which class II antigens on targets cells were blocked with monoclonal anti-class II antibody (DA6,231) and the cytotoxic reaction induced by patient's sera was abolished. In contrast, ADCC was not impaired by preincubating the target cells with anti-class I monoclonal antibody (W6/32). Prevalence of antibodies to non-T cells was confirmed by standard C-mediated micro-lymphocytotoxicity. However, with this technique anti-T lymphocyte cytotoxicity was also observed in three AIDS patients with haemophilia.
ISSN:0019-2805