Styrene-Oxide N-Terminal Valine Haelmoglobin Adducts in Reinforced Plastic Workers: Possible Influence of Genetic Polymorphism of Drug-Metabolising Enzymes

The possible influence of individual genetic polymorphisms of styrene-metabolizing enzymes on the level of urinary styrene metabolites and styrene oxide adducts with N-terminal valine of human globin (SO-Hb) following occupational exposure to styrene was evaluated. Urinalysis was performed using a h...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2007-07, Vol.237 (1), p.58-58
Main Authors: Teixeira, J P, Gaspar, J, Roma-Torres, J, Silva, S, Costa, C, Roach, J, Mayan, O
Format: Article
Language:English
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Summary:The possible influence of individual genetic polymorphisms of styrene-metabolizing enzymes on the level of urinary styrene metabolites and styrene oxide adducts with N-terminal valine of human globin (SO-Hb) following occupational exposure to styrene was evaluated. Urinalysis was performed using a high-pressure liquid chromatography method. In all urine samples, creatinine (Cr) was measured according to Jaffe's method and the values of mandelic acid (MA) and phenylglyoxylic acid (PGA) were expressed as mg/g Cr. Results showed that MA + PGA levels in the control group were below the limit of detection. Levels of SO-Hb adducts were significantly higher in the exposed subjects when compared with controls. Among the control subjects the smokers had a significant increase of SO-Hb adducts when compared with the non-smokers.
ISSN:0300-483X