Sodium-independent in vitro induction of Na super(+),K super(+)-ATPase by aldosterone in renal target cells: Permissive effect of triiodothyronine

The aim of this study was to develop an in vitro system in which the authors could study the causal relationship between short-term stimulation of Na super(+),K super(+)-ATPase in the collecting tubule by aldosterone on the one hand and protein synthesis and changes in intracellular Na super(+) conc...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1988-01, Vol.85 (5), p.1707-1711
Main Authors: Barlet-Bas, C, Khadouri, C, Marsy, S, Doucet, A
Format: Article
Language:English
Subjects:
3,5,3'-triiodothyronine
adenosinetriphosphatase
aldosterone
kidney
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Summary:The aim of this study was to develop an in vitro system in which the authors could study the causal relationship between short-term stimulation of Na super(+),K super(+)-ATPase in the collecting tubule by aldosterone on the one hand and protein synthesis and changes in intracellular Na super(+) concentration on the other hand. Triiodothyronine facilitates the in vitro induction of Na super(+),K super(+)-ATPase synthesis by aldosterone. Aldosterone action on Na super(+),K super(+)-ATPase is independent of Na super(+) availability.
ISSN:0027-8424