Disposition of Decamethylcyclopentasiloxane in Fischer 344 Rats Following Single or Repeated Inhalation Exposure to super(14)C-Decamethylcyclopentasiloxane ( super(14)C-D sub(5))

Effects of dose and gender on the distribution and pathways for elimination of decamethylcyclopentasiloxane (D sub(5)) and its radioactive metabolites after a single inhalation exposure to super(14)C-D sub(5) are assessed. Pharmacokinetic parameters and elimination pathways of radioactivity obtained...

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Bibliographic Details
Published in:Inhalation toxicology 2008-01, Vol.20 (5), p.513-513
Main Authors: Tobin, Joseph M, McNett, Debra A, Durham, Jeremy A, Plotzke, Kathleen P
Format: Article
Language:English
Online Access:Get full text
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Summary:Effects of dose and gender on the distribution and pathways for elimination of decamethylcyclopentasiloxane (D sub(5)) and its radioactive metabolites after a single inhalation exposure to super(14)C-D sub(5) are assessed. Pharmacokinetic parameters and elimination pathways of radioactivity obtained here represent composite parameters of D sub(5) and its metabolites. Kinetic analyses of these data provide a basis for estimating the amount of time required to achieve a specified level of clearance of D sub(5) and/or its metabolites from rats. Data developed using super(14)C-D sub(5), in combination with the parent analysis provide general information about the metabolism of D sub(5) and may establish parameters for designing more specific studies. There are no differences observed for D sub(5) elimination pathways based on gender or dose between single or repeated exposures to 160 ppm.
ISSN:0895-8378