Clinical association of anticentromere antibodies and antibodies to topoisomerase I. A study of 355 patients

Anticentromere antibodies (ACA) and anti-topoisomerase I (anti-topo I) were assayed in serum samples from 355 patients: 89 with proximal scleroderma; 54 with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias), without proximal scleroderma;...

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Published in:Arthritis and rheumatism 1988-01, Vol.31 (3), p.378-385
Main Authors: Weiner, E S, Earnshaw, W C, Senecal, J-L, Bordwell, B, Johnson, P, Rothfield, N F
Format: Article
Language:English
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Summary:Anticentromere antibodies (ACA) and anti-topoisomerase I (anti-topo I) were assayed in serum samples from 355 patients: 89 with proximal scleroderma; 54 with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias), without proximal scleroderma; 154 with primary and secondary Raynaud's disease; and 58 with other rheumatic diseases, without Raynaud's disease. Sera from healthy control subjects were also assayed.
ISSN:0004-3591