Comparison of spectral-domain and high-penetration OCT for observing morphologic changes in age-related macular degeneration and polypoidal choroidal vasculopathy

Background We compared the visibility of retinal and choroidal pathologies using high-penetration optical coherence tomography (HP-OCT) with a long-wavelength light source (1,050 nm) and conventional spectral-domain OCT (SD-OCT) in age-related macular degeneration (AMD). Methods One hundred and fort...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 2014, Vol.252 (1), p.3-9
Main Authors: Sayanagi, Kaori, Gomi, Fumi, Ikuno, Yasushi, Akiba, Masahiro, Nishida, Kohji
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Angiogenesis Inhibitors - therapeutic use
Choroid - pathology
Choroidal Neovascularization - diagnosis
Coloring Agents
Female
Fluorescein Angiography
Humans
Indocyanine Green
Macular degeneration
Macular Degeneration - diagnosis
Macular Degeneration - drug therapy
Male
Medicine
Medicine & Public Health
Middle Aged
Ophthalmology
Photochemotherapy
Polyps - diagnosis
Retina - pathology
Tomography, Optical Coherence - methods
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Summary:Background We compared the visibility of retinal and choroidal pathologies using high-penetration optical coherence tomography (HP-OCT) with a long-wavelength light source (1,050 nm) and conventional spectral-domain OCT (SD-OCT) in age-related macular degeneration (AMD). Methods One hundred and forty-six eyes were included: 63 eyes with AMD, 79 eyes with polypoidal choroidal vasculopathy (PCV), and four eyes with retinal angiomatous proliferation. The SD-OCT and HP-OCT images were compared using the grading criteria to grade the visibility of the retinal changes, the line corresponding to the retinal pigment epithelium (RPE), and the chorioscleral interface (CSI). In 132 eyes with a pigment epithelial detachment (PED), we graded the structures inside the PED, Bruch’s line, and the CSI. We compared the visibility of those changes in eyes with subretinal hyperreflective changes due to a subretinal hemorrhage (SRH) ( n  = 17) or a hemorrhage inside the PED (HPED) ( n  = 12). Results HP-OCT provided superior visibility of the following structures compared to SD-OCT ( P  
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-013-2474-5