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Changes in matrix metalloproteinase-9 levels during progression of atrial fibrillation
Objectives: To observe levels of matrix metalloproteinase (MMP)-9 and evaluate their significance in various stages of idiopathic atrial fibrillation (AF). Methods: Patients with idiopathic AF were recruited into this prospective study and classified into one of three groups according to stage of di...
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| Published in: | Journal of international medical research 2014-02, Vol.42 (1), p.224-230 |
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| Main Authors: | , , , , |
| Format: | Article |
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| cites | cdi_FETCH-LOGICAL-c409t-4e0e0e28ddb7573b07b68a4b0a936633e3231c508cb234ee9f1b9ec97c7304d13 |
| container_end_page | 230 |
| container_issue | 1 |
| container_start_page | 224 |
| container_title | Journal of international medical research |
| container_volume | 42 |
| creator | Li, Mingjiang Yang, Guokang Xie, Bin Babu, Kamesh Huang, Congxin |
| description | Objectives:
To observe levels of matrix metalloproteinase (MMP)-9 and evaluate their significance in various stages of idiopathic atrial fibrillation (AF).
Methods:
Patients with idiopathic AF were recruited into this prospective study and classified into one of three groups according to stage of disease progression: paroxysmal AF; persistent AF; permanent AF. Healthy individuals were enrolled as control subjects. Serum levels of MMP-9 in all four groups were determined using a double-antibody sandwich enzyme-linked immunosorbent assay.
Results:
Each AF group included 25 patients; 40 healthy individuals were included as controls. MMP-9 levels in the three AF groups were significantly higher than in the control group: 168.72 ± 25.970, 201.36 ± 31.26 and 253.20 ± 22.99 ng/ml for the paroxysmal, persistent and permanent AF groups respectively, versus 76.80 ± 14.90 ng/ml for the control group. MMP-9 levels increased with idiopathic AF disease progression (P |
| doi_str_mv | 10.1177/0300060513488514 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1490722195</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0300060513488514</sage_id><sourcerecordid>1490722195</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-4e0e0e28ddb7573b07b68a4b0a936633e3231c508cb234ee9f1b9ec97c7304d13</originalsourceid><addsrcrecordid>eNp1kM1LxDAQxYMo7rp69yS5CF6qk4827VEWv2DBi3otaTpds6TtmrSi_71ZdlUQZA4D835vZniEnDK4ZEypKxAAkEHKhMzzlMk9MmVSiYTH-T6ZbuRko0_IUQgrAMmzlB-SCZdCpjkXU_Iyf9XdEgO1HW314O0HbXHQzvVr3w9oOx0wKajDd3SB1qO33ZJGaekxBNt3tG_oxqYdbWzlrXN6iONjctBoF_Bk12fk-fbmaX6fLB7vHubXi8RIKIZEIsTieV1XKlWiAlVluZYV6EJkmRAouGAmhdxUXEjEomFVgaZQRgmQNRMzcrHdG196GzEMZWuDwfhFh_0YSiYLUJyzIo0obFHj-xA8NuXa21b7z5JBuUmz_JtmtJztto9Vi_WP4Tu-CJzvAB2Mdo3XnbHhl8t5CkLlkUu2XNBLLFf96LuYyv-HvwCq8Ikl</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1490722195</pqid></control><display><type>article</type><title>Changes in matrix metalloproteinase-9 levels during progression of atrial fibrillation</title><source>SAGE Open Access</source><creator>Li, Mingjiang ; Yang, Guokang ; Xie, Bin ; Babu, Kamesh ; Huang, Congxin</creator><creatorcontrib>Li, Mingjiang ; Yang, Guokang ; Xie, Bin ; Babu, Kamesh ; Huang, Congxin</creatorcontrib><description>Objectives:
To observe levels of matrix metalloproteinase (MMP)-9 and evaluate their significance in various stages of idiopathic atrial fibrillation (AF).
Methods:
Patients with idiopathic AF were recruited into this prospective study and classified into one of three groups according to stage of disease progression: paroxysmal AF; persistent AF; permanent AF. Healthy individuals were enrolled as control subjects. Serum levels of MMP-9 in all four groups were determined using a double-antibody sandwich enzyme-linked immunosorbent assay.
Results:
Each AF group included 25 patients; 40 healthy individuals were included as controls. MMP-9 levels in the three AF groups were significantly higher than in the control group: 168.72 ± 25.970, 201.36 ± 31.26 and 253.20 ± 22.99 ng/ml for the paroxysmal, persistent and permanent AF groups respectively, versus 76.80 ± 14.90 ng/ml for the control group. MMP-9 levels increased with idiopathic AF disease progression (P < 0.05).
Conclusions:
An elevated MMP-9 level appears to be associated with a diagnosis of AF. MMP-9 levels appear to increase in relation to the stage of idiopathic AF progression.</description><identifier>ISSN: 0300-0605</identifier><identifier>EISSN: 1473-2300</identifier><identifier>DOI: 10.1177/0300060513488514</identifier><identifier>PMID: 24345823</identifier><identifier>CODEN: JIMRBV</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Aged ; Atrial Fibrillation - enzymology ; Biological and medical sciences ; Cardiac dysrhythmias ; Cardiology. Vascular system ; Case-Control Studies ; Disease Progression ; Enzyme-Linked Immunosorbent Assay ; Female ; Heart ; Humans ; Male ; Matrix Metalloproteinase 9 - metabolism ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Prospective Studies</subject><ispartof>Journal of international medical research, 2014-02, Vol.42 (1), p.224-230</ispartof><rights>The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-4e0e0e28ddb7573b07b68a4b0a936633e3231c508cb234ee9f1b9ec97c7304d13</citedby><cites>FETCH-LOGICAL-c409t-4e0e0e28ddb7573b07b68a4b0a936633e3231c508cb234ee9f1b9ec97c7304d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0300060513488514$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0300060513488514$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,21945,27830,27901,27902,44921,45309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28250378$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24345823$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Mingjiang</creatorcontrib><creatorcontrib>Yang, Guokang</creatorcontrib><creatorcontrib>Xie, Bin</creatorcontrib><creatorcontrib>Babu, Kamesh</creatorcontrib><creatorcontrib>Huang, Congxin</creatorcontrib><title>Changes in matrix metalloproteinase-9 levels during progression of atrial fibrillation</title><title>Journal of international medical research</title><addtitle>J Int Med Res</addtitle><description>Objectives:
To observe levels of matrix metalloproteinase (MMP)-9 and evaluate their significance in various stages of idiopathic atrial fibrillation (AF).
Methods:
Patients with idiopathic AF were recruited into this prospective study and classified into one of three groups according to stage of disease progression: paroxysmal AF; persistent AF; permanent AF. Healthy individuals were enrolled as control subjects. Serum levels of MMP-9 in all four groups were determined using a double-antibody sandwich enzyme-linked immunosorbent assay.
Results:
Each AF group included 25 patients; 40 healthy individuals were included as controls. MMP-9 levels in the three AF groups were significantly higher than in the control group: 168.72 ± 25.970, 201.36 ± 31.26 and 253.20 ± 22.99 ng/ml for the paroxysmal, persistent and permanent AF groups respectively, versus 76.80 ± 14.90 ng/ml for the control group. MMP-9 levels increased with idiopathic AF disease progression (P < 0.05).
Conclusions:
An elevated MMP-9 level appears to be associated with a diagnosis of AF. MMP-9 levels appear to increase in relation to the stage of idiopathic AF progression.</description><subject>Adult</subject><subject>Aged</subject><subject>Atrial Fibrillation - enzymology</subject><subject>Biological and medical sciences</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Disease Progression</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Matrix Metalloproteinase 9 - metabolism</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><issn>0300-0605</issn><issn>1473-2300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><recordid>eNp1kM1LxDAQxYMo7rp69yS5CF6qk4827VEWv2DBi3otaTpds6TtmrSi_71ZdlUQZA4D835vZniEnDK4ZEypKxAAkEHKhMzzlMk9MmVSiYTH-T6ZbuRko0_IUQgrAMmzlB-SCZdCpjkXU_Iyf9XdEgO1HW314O0HbXHQzvVr3w9oOx0wKajDd3SB1qO33ZJGaekxBNt3tG_oxqYdbWzlrXN6iONjctBoF_Bk12fk-fbmaX6fLB7vHubXi8RIKIZEIsTieV1XKlWiAlVluZYV6EJkmRAouGAmhdxUXEjEomFVgaZQRgmQNRMzcrHdG196GzEMZWuDwfhFh_0YSiYLUJyzIo0obFHj-xA8NuXa21b7z5JBuUmz_JtmtJztto9Vi_WP4Tu-CJzvAB2Mdo3XnbHhl8t5CkLlkUu2XNBLLFf96LuYyv-HvwCq8Ikl</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Li, Mingjiang</creator><creator>Yang, Guokang</creator><creator>Xie, Bin</creator><creator>Babu, Kamesh</creator><creator>Huang, Congxin</creator><general>SAGE Publications</general><general>Sage Publications</general><scope>AFRWT</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140201</creationdate><title>Changes in matrix metalloproteinase-9 levels during progression of atrial fibrillation</title><author>Li, Mingjiang ; Yang, Guokang ; Xie, Bin ; Babu, Kamesh ; Huang, Congxin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-4e0e0e28ddb7573b07b68a4b0a936633e3231c508cb234ee9f1b9ec97c7304d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Atrial Fibrillation - enzymology</topic><topic>Biological and medical sciences</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Disease Progression</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Matrix Metalloproteinase 9 - metabolism</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Mingjiang</creatorcontrib><creatorcontrib>Yang, Guokang</creatorcontrib><creatorcontrib>Xie, Bin</creatorcontrib><creatorcontrib>Babu, Kamesh</creatorcontrib><creatorcontrib>Huang, Congxin</creatorcontrib><collection>SAGE Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of international medical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Mingjiang</au><au>Yang, Guokang</au><au>Xie, Bin</au><au>Babu, Kamesh</au><au>Huang, Congxin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in matrix metalloproteinase-9 levels during progression of atrial fibrillation</atitle><jtitle>Journal of international medical research</jtitle><addtitle>J Int Med Res</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>42</volume><issue>1</issue><spage>224</spage><epage>230</epage><pages>224-230</pages><issn>0300-0605</issn><eissn>1473-2300</eissn><coden>JIMRBV</coden><abstract>Objectives:
To observe levels of matrix metalloproteinase (MMP)-9 and evaluate their significance in various stages of idiopathic atrial fibrillation (AF).
Methods:
Patients with idiopathic AF were recruited into this prospective study and classified into one of three groups according to stage of disease progression: paroxysmal AF; persistent AF; permanent AF. Healthy individuals were enrolled as control subjects. Serum levels of MMP-9 in all four groups were determined using a double-antibody sandwich enzyme-linked immunosorbent assay.
Results:
Each AF group included 25 patients; 40 healthy individuals were included as controls. MMP-9 levels in the three AF groups were significantly higher than in the control group: 168.72 ± 25.970, 201.36 ± 31.26 and 253.20 ± 22.99 ng/ml for the paroxysmal, persistent and permanent AF groups respectively, versus 76.80 ± 14.90 ng/ml for the control group. MMP-9 levels increased with idiopathic AF disease progression (P < 0.05).
Conclusions:
An elevated MMP-9 level appears to be associated with a diagnosis of AF. MMP-9 levels appear to increase in relation to the stage of idiopathic AF progression.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>24345823</pmid><doi>10.1177/0300060513488514</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0300-0605 |
| ispartof | Journal of international medical research, 2014-02, Vol.42 (1), p.224-230 |
| issn | 0300-0605 1473-2300 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1490722195 |
| source | SAGE Open Access |
| subjects | Adult Aged Atrial Fibrillation - enzymology Biological and medical sciences Cardiac dysrhythmias Cardiology. Vascular system Case-Control Studies Disease Progression Enzyme-Linked Immunosorbent Assay Female Heart Humans Male Matrix Metalloproteinase 9 - metabolism Medical sciences Middle Aged Pharmacology. Drug treatments Prospective Studies |
| title | Changes in matrix metalloproteinase-9 levels during progression of atrial fibrillation |
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