Renal Function After Nephron-sparing Surgery Versus Radical Nephrectomy: Results from EORTC Randomized Trial 30904

Abstract Background In the European Organization for Research and Treatment of Cancer (EORTC) randomized trial 30904, nephron-sparing surgery (NSS) was associated with reduced overall survival compared with radical nephrectomy (RN) over a median follow-up of 9.3 yr (hazard ratio: 1.50; 95% confidenc...

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Bibliographic Details
Published in:European urology 2014-02, Vol.65 (2), p.372-377
Main Authors: Scosyrev, Emil, Messing, Edward M, Sylvester, Richard, Campbell, Steven, Van Poppel, Hendrik
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Female
Glomerular Filtration Rate
Humans
Incidence
Kidney cancer
Kidney Neoplasms - mortality
Kidney Neoplasms - pathology
Kidney Neoplasms - physiopathology
Kidney Neoplasms - surgery
Kidneys
Male
Medical sciences
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Nephrectomy - adverse effects
Nephrectomy - methods
Nephrectomy - mortality
Nephrology. Urinary tract diseases
Nephron-sparing surgery
Nephrons - pathology
Nephrons - physiopathology
Nephrons - surgery
Organ Sparing Treatments - adverse effects
Organ Sparing Treatments - mortality
Radical nephrectomy
Renal Insufficiency - diagnosis
Renal Insufficiency - etiology
Renal Insufficiency - mortality
Renal Insufficiency - physiopathology
Risk Factors
Time Factors
Treatment Outcome
Tumors
Tumors of the urinary system
Urology
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Summary:Abstract Background In the European Organization for Research and Treatment of Cancer (EORTC) randomized trial 30904, nephron-sparing surgery (NSS) was associated with reduced overall survival compared with radical nephrectomy (RN) over a median follow-up of 9.3 yr (hazard ratio: 1.50; 95% confidence interval [CI], 1.03–2.16). Objective To examine the impact of NSS relative to RN on kidney function in EORTC 30904. Design, setting, and participants This phase 3 international randomized trial was conducted in patients with a small (≤5 cm) renal mass and normal contralateral kidney who were enrolled from March 1992 to January 2003. Intervention Patients were randomized to RN ( n = 273) or NSS ( n = 268). Outcome measurements and statistical analysis Follow-up estimated glomerular filtration rates (eGFR; milliliters per minute per 1.73 m2 ) were recorded for 259 subjects in the RN arm and 255 subjects in the NSS arm. Percentages of subjects developing at least moderate renal dysfunction (eGFR
ISSN:0302-2838
1873-7560
DOI:10.1016/j.eururo.2013.06.044