Measurement of the apparent diffusion coefficient in paediatric mitochondrial encephalopathy cases and a comparison of parenchymal changes associated with the disease using follow-up diffusion coefficient measurements

Highlights • DWI complements conventional MRI in diagnosing mitochondrial encephalopathy (ME) in paediatric patients. • DWI can determine lesion degeneration rate in regions with no signal change. • DWI is useful in the follow-up of ME progression. • Apparent diffusion coefficient (ADC) values can i...

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Bibliographic Details
Published in:European journal of radiology 2014-01, Vol.83 (1), p.212-218
Main Authors: Uysal, Fatma, Çakmakçı, Handan, Yiş, Uluç, Ellidokuz, Hülya, Hız, Ayşe Semra
Format: Article
Language:English
Subjects:
Algorithms
Brain - pathology
Brain ADC
Child
Child, Preschool
Diffusion Magnetic Resonance Imaging - methods
Diffusion-weighted magnetic resonance imaging
Female
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Infant
Magnetic resonance imaging
Male
Mitochondrial Encephalomyopathies - pathology
Mitochondrial encephalopathy
Radiology
Reproducibility of Results
Sensitivity and Specificity
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Summary:Highlights • DWI complements conventional MRI in diagnosing mitochondrial encephalopathy (ME) in paediatric patients. • DWI can determine lesion degeneration rate in regions with no signal change. • DWI is useful in the follow-up of ME progression. • Apparent diffusion coefficient (ADC) values can indicate in-lesion degeneration and ME progression. • ADC measurement should be included in routine brain MRI examination.
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2013.06.031