Sudden, unexpected infant death due to pulmonary arterial hypertension

Abstract A 3-year-old girl with no particular medical history complained of a stomachache and died on the way to the hospital. The autopsy revealed marked right ventricular hypertrophy and dilation with no other cardiac abnormalities. Microscopically, the pulmonary small arteries showed marked media...

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Bibliographic Details
Published in:Legal medicine (Tokyo, Japan) Japan), 2014-01, Vol.16 (1), p.44-47
Main Authors: Igari, Yui, Hosoya, Tadashi, Hayashizaki, Yoshie, Ohuchi, Tsukasa, Usui, Akihito, Kawasumi, Yusuke, Hashiyada, Masaki, Funayama, Masato
Format: Article
Language:English
Subjects:
Autopsy
Cause of Death
Child, Preschool
Death, Sudden
Female
Humans
Hypertension, Pulmonary - diagnostic imaging
Hypertension, Pulmonary - pathology
Internal Medicine
Pulmonary arterial hypertension (PAH)
Radiography
Right ventricular hypertrophy
Sudden death in infancy
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Summary:Abstract A 3-year-old girl with no particular medical history complained of a stomachache and died on the way to the hospital. The autopsy revealed marked right ventricular hypertrophy and dilation with no other cardiac abnormalities. Microscopically, the pulmonary small arteries showed marked medial hypertrophy and varying degrees of intimal and adventitial thickening. We supposed that the cause of death was attributable to pulmonary arterial hypertension (PAH). PAH is a rare disease that can cause sudden, unexpected death at any age. Forensic pathologists should consider PAH in the differential diagnosis of sudden death.
ISSN:1344-6223
1873-4162
DOI:10.1016/j.legalmed.2013.11.001