Osteoporosis and sarcopenia: the connections

Osteoporosis and sarcopenia are the most frequent musculoskeletal disorders affecting older people. Osteoporosis is a widespread disorder affecting millions of individuals of all ethnic backgrounds worldwide, particularly among older women. It is characterized by reduced bone mass and microarchitect...

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Bibliographic Details
Published in:Aging clinical and experimental research 2013-10, Vol.25 (Suppl 1), p.93-95
Main Authors: Tarantino, Umberto, Baldi, Jacopo, Celi, Monica, Rao, Cecilia, Liuni, Federico Maria, Iundusi, Riccardo, Gasbarra, Elena
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
Bone and Bones - metabolism
Estrogens - blood
Female
Frail Elderly
Geriatrics/Gerontology
Human Growth Hormone - blood
Humans
Insulin-Like Growth Factor I - metabolism
Medicine
Medicine & Public Health
Middle Aged
Muscle, Skeletal - pathology
Muscles - pathology
Muscular Atrophy - pathology
Osteoblasts - metabolism
Osteoporosis
Osteoporosis - complications
Quality of Life
Sarcopenia
Sarcopenia - complications
Short Communication
Testosterone - blood
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Summary:Osteoporosis and sarcopenia are the most frequent musculoskeletal disorders affecting older people. Osteoporosis is a widespread disorder affecting millions of individuals of all ethnic backgrounds worldwide, particularly among older women. It is characterized by reduced bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in the risk of fracture. Sarcopenia is considered to be one of the major factors responsible for functional limitations and motor dependency in elderly persons. In age-related muscle atrophy, a decrease in muscle fiber size and number, and a preferential loss of type II fibers have been reported. A decrease in the circulating levels of specific hormones (e.g., estrogen, testosterone, growth hormone, and insulin-like growth factor-1) has been shown to be associated with sarcopenia and this appears to play an important role in its pathogenesis.
ISSN:1720-8319
1594-0667
1720-8319
DOI:10.1007/s40520-013-0097-7