Gallium nitrate induces fibrinogen flocculation: an explanation for its hemostatic effect?

A novel hemostatic effect of gallium nitrate has recently been discovered. Our aim was to perform a preliminary investigation into its mode of action. Thromboelastography ® showed no effect on coagulation but pointed instead to changes in fibrinogen concentration. We measured functional fibrinogen i...

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Bibliographic Details
Published in:Biometals 2013-12, Vol.26 (6), p.935-939
Main Authors: Bauters, A., Holt, D. J., Zerbib, P., Rogosnitzky, M.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biophysics
Blood
Blood Cells - drug effects
Cell Biology
Cells, Cultured
Dose-Response Relationship, Drug
Fibrinogen - agonists
Fibrinogen - chemistry
Flocculation
Gallium
Gallium - pharmacology
Hemostasis - drug effects
Humans
Hydrogen-Ion Concentration
Life Sciences
Medicine/Public Health
Metals
Microbiology
Mode of action
Nitrates
Nitric acid
Nitric Acid - pharmacology
Pharmacology
Pharmacology/Toxicology
Plant Physiology
Proteins
Whole Blood Coagulation Time
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Summary:A novel hemostatic effect of gallium nitrate has recently been discovered. Our aim was to perform a preliminary investigation into its mode of action. Thromboelastography ® showed no effect on coagulation but pointed instead to changes in fibrinogen concentration. We measured functional fibrinogen in whole blood after addition of gallium nitrate and nitric acid. We found that gallium nitrate induces fibrinogen precipitation in whole blood to a significantly higher degree than solutions of nitric acid alone. This precipitate is not primarily pH driven, and appears to occur via flocculation. This behavior is in line with the generally observed ability of metals to induce fibrinogen precipitation. Further investigation is required into this novel phenomenon.
ISSN:0966-0844
1572-8773
DOI:10.1007/s10534-013-9669-4