CD137 as a Biomarker for Tumor-Reactive T Cells: Finding Gold in the Desert

Although human cancer is often surrounded by immune cells, only a small number are tumor-reactive T cells that recognize the tumor antigens and are able to eliminate the cancer cells. Ye and colleagues now found that many of these tumor-reactive T cells are marked by expressing CD137, a T-cell costi...

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Bibliographic Details
Published in:Clinical cancer research 2014, Vol.20 (1), p.3-5
Main Authors: Zhu, Yuwen, Chen, Lieping
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Female
Humans
Medical sciences
Melanoma - immunology
Ovarian Neoplasms - immunology
Pharmacology. Drug treatments
T-Lymphocytes - metabolism
Tumor Necrosis Factor Receptor Superfamily, Member 9 - metabolism
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Summary:Although human cancer is often surrounded by immune cells, only a small number are tumor-reactive T cells that recognize the tumor antigens and are able to eliminate the cancer cells. Ye and colleagues now found that many of these tumor-reactive T cells are marked by expressing CD137, a T-cell costimulatory receptor.
ISSN:1078-0432
1557-3265
DOI:10.1158/1078-0432.CCR-13-2573