Does MBL2 codon 54 polymorphism play a role in the pathogenesis of psoriasis?

Background  Psoriasis is a T cell‐mediated immune disease in which various cytokines, primarily tumor necrosis factor‐α (TNF‐α), are complexly involved. Mannose‐binding lectin (MBL) gene polymorphisms decrease MBL serum levels, thereby increasing the synthesis of proinflammatory cytokines such as TN...

Full description

Saved in:
Bibliographic Details
Published in:International journal of dermatology 2014-01, Vol.53 (1), p.34-38
Main Authors: Turan, Hakan, Karkucak, Mutlu, Yakut, Tahsin, Ozsahin, Mustafa, Gurlevik, Zehra, Yanik, Mehmet Emin, Ucgun, Taner, Aliagaoglu, Cihangir, Yaykasli, Kursat Oguz
Format: Article
Language:English
Subjects:
Adult
Codon - genetics
Female
Gene Frequency
Genotype
Humans
Male
Mannose-Binding Lectin - genetics
Middle Aged
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Psoriasis - etiology
Psoriasis - genetics
Turkey
Young Adult
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background  Psoriasis is a T cell‐mediated immune disease in which various cytokines, primarily tumor necrosis factor‐α (TNF‐α), are complexly involved. Mannose‐binding lectin (MBL) gene polymorphisms decrease MBL serum levels, thereby increasing the synthesis of proinflammatory cytokines such as TNF‐α. Objectives  This trial was designed to evaluate the role of the MBL2 codon 54 polymorphism in the pathogenesis of psoriasis. Methods  Fifty patients diagnosed with psoriasis vulgaris and 53 healthy subjects were included in the trial. The polymerase chain reaction–restriction fragment length polymorphism (PCR‐RFLP) method was applied to determine the MBL2 codon 54 polymorphism. Genotypes were determined according to the bands formed in agarose electrophoresis gels. For the statistical analysis, the level of significance was set at P 
ISSN:0011-9059
1365-4632
DOI:10.1111/j.1365-4632.2012.5657.x