Does MBL2 codon 54 polymorphism play a role in the pathogenesis of psoriasis?

Background  Psoriasis is a T cell‐mediated immune disease in which various cytokines, primarily tumor necrosis factor‐α (TNF‐α), are complexly involved. Mannose‐binding lectin (MBL) gene polymorphisms decrease MBL serum levels, thereby increasing the synthesis of proinflammatory cytokines such as TN...

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Published in:International journal of dermatology 2014-01, Vol.53 (1), p.34-38
Main Authors: Turan, Hakan, Karkucak, Mutlu, Yakut, Tahsin, Ozsahin, Mustafa, Gurlevik, Zehra, Yanik, Mehmet Emin, Ucgun, Taner, Aliagaoglu, Cihangir, Yaykasli, Kursat Oguz
Format: Article
Language:English
Subjects:
Adult
Codon - genetics
Female
Gene Frequency
Genotype
Humans
Male
Mannose-Binding Lectin - genetics
Middle Aged
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Psoriasis - etiology
Psoriasis - genetics
Turkey
Young Adult
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container_issue 1
container_start_page 34
container_title International journal of dermatology
container_volume 53
creator Turan, Hakan
Karkucak, Mutlu
Yakut, Tahsin
Ozsahin, Mustafa
Gurlevik, Zehra
Yanik, Mehmet Emin
Ucgun, Taner
Aliagaoglu, Cihangir
Yaykasli, Kursat Oguz
description Background  Psoriasis is a T cell‐mediated immune disease in which various cytokines, primarily tumor necrosis factor‐α (TNF‐α), are complexly involved. Mannose‐binding lectin (MBL) gene polymorphisms decrease MBL serum levels, thereby increasing the synthesis of proinflammatory cytokines such as TNF‐α. Objectives  This trial was designed to evaluate the role of the MBL2 codon 54 polymorphism in the pathogenesis of psoriasis. Methods  Fifty patients diagnosed with psoriasis vulgaris and 53 healthy subjects were included in the trial. The polymerase chain reaction–restriction fragment length polymorphism (PCR‐RFLP) method was applied to determine the MBL2 codon 54 polymorphism. Genotypes were determined according to the bands formed in agarose electrophoresis gels. For the statistical analysis, the level of significance was set at P 
doi_str_mv 10.1111/j.1365-4632.2012.5657.x
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Mannose‐binding lectin (MBL) gene polymorphisms decrease MBL serum levels, thereby increasing the synthesis of proinflammatory cytokines such as TNF‐α. Objectives  This trial was designed to evaluate the role of the MBL2 codon 54 polymorphism in the pathogenesis of psoriasis. Methods  Fifty patients diagnosed with psoriasis vulgaris and 53 healthy subjects were included in the trial. The polymerase chain reaction–restriction fragment length polymorphism (PCR‐RFLP) method was applied to determine the MBL2 codon 54 polymorphism. Genotypes were determined according to the bands formed in agarose electrophoresis gels. For the statistical analysis, the level of significance was set at P &lt; 0.05. Results  A total of 33 (66.0%) of the 50 psoriasis patients were detected to have A/A genotype and 17 (34.0%) had B/B genotype. Of the control subjects, 44 (83.0%) had A/A genotype and nine (17.0%) had B/B genotype. There was a statistically significant difference between the groups (P = 0.047). The analysis of allele frequencies revealed A allele prevalences to be 79 (79.0%) and 95 (89.6%), and B allele prevalences to be 21 (21.0%) and 11 (10.4%), in the patient and control groups, respectively. A statistically significant difference between allele frequencies was detected (P = 0.031). Conclusions  This study suggests that the MBL2 codon 54 polymorphism may have an association with psoriasis in the Turkish population.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/j.1365-4632.2012.5657.x</identifier><identifier>PMID: 23113841</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Codon - genetics ; Female ; Gene Frequency ; Genotype ; Humans ; Male ; Mannose-Binding Lectin - genetics ; Middle Aged ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Psoriasis - etiology ; Psoriasis - genetics ; Turkey ; Young Adult</subject><ispartof>International journal of dermatology, 2014-01, Vol.53 (1), p.34-38</ispartof><rights>2012 The International Society of Dermatology</rights><rights>2012 The International Society of Dermatology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3567-e881e6961f3a70fb7038dbea19f2e3f58f1c033aff68690598ca3042e8d0b7d13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23113841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Turan, Hakan</creatorcontrib><creatorcontrib>Karkucak, Mutlu</creatorcontrib><creatorcontrib>Yakut, Tahsin</creatorcontrib><creatorcontrib>Ozsahin, Mustafa</creatorcontrib><creatorcontrib>Gurlevik, Zehra</creatorcontrib><creatorcontrib>Yanik, Mehmet Emin</creatorcontrib><creatorcontrib>Ucgun, Taner</creatorcontrib><creatorcontrib>Aliagaoglu, Cihangir</creatorcontrib><creatorcontrib>Yaykasli, Kursat Oguz</creatorcontrib><title>Does MBL2 codon 54 polymorphism play a role in the pathogenesis of psoriasis?</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background  Psoriasis is a T cell‐mediated immune disease in which various cytokines, primarily tumor necrosis factor‐α (TNF‐α), are complexly involved. Mannose‐binding lectin (MBL) gene polymorphisms decrease MBL serum levels, thereby increasing the synthesis of proinflammatory cytokines such as TNF‐α. Objectives  This trial was designed to evaluate the role of the MBL2 codon 54 polymorphism in the pathogenesis of psoriasis. Methods  Fifty patients diagnosed with psoriasis vulgaris and 53 healthy subjects were included in the trial. The polymerase chain reaction–restriction fragment length polymorphism (PCR‐RFLP) method was applied to determine the MBL2 codon 54 polymorphism. Genotypes were determined according to the bands formed in agarose electrophoresis gels. For the statistical analysis, the level of significance was set at P &lt; 0.05. Results  A total of 33 (66.0%) of the 50 psoriasis patients were detected to have A/A genotype and 17 (34.0%) had B/B genotype. Of the control subjects, 44 (83.0%) had A/A genotype and nine (17.0%) had B/B genotype. There was a statistically significant difference between the groups (P = 0.047). The analysis of allele frequencies revealed A allele prevalences to be 79 (79.0%) and 95 (89.6%), and B allele prevalences to be 21 (21.0%) and 11 (10.4%), in the patient and control groups, respectively. A statistically significant difference between allele frequencies was detected (P = 0.031). Conclusions  This study suggests that the MBL2 codon 54 polymorphism may have an association with psoriasis in the Turkish population.</description><subject>Adult</subject><subject>Codon - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Mannose-Binding Lectin - genetics</subject><subject>Middle Aged</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Psoriasis - etiology</subject><subject>Psoriasis - genetics</subject><subject>Turkey</subject><subject>Young Adult</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNo9kMtOwzAQRS0EgvL4BfCSTYLHTuxEQkK0QAEVEAgEO8tNxjQlqUPcivbvSVTobOZ172h0CDkBFkIbZ9MQhIyDSAoecgY8jGWswuUW6W3m26THGECQsjjdI_veT9tWcIh2yR4XACKJoEcerhx6-tAfcZq53M1oHNHalavKNfWk8BWtS7OihjauRFrM6HyCtDbzifvEGfrCU2dp7V1TmLa5OCQ71pQej_7yAXm7uX4d3Aajp-Hd4HIUZCKWKsAkAZSpBCuMYnasmEjyMRpILUdh48RCxoQw1spEdv8nmREs4pjkbKxyEAfkdH23btz3Av1cV4XPsCzNDN3Ca4hSpiJIlWqlx3_SxbjCXNdNUZlmpf8RtILzteCnKHG12QPTHWk91R1R3RHVHWndkdZLfXd_1VWtPVjbCz_H5cZumi8tlVCxfn8c6ui5P_x4fOF6IH4BNOp-tw</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Turan, Hakan</creator><creator>Karkucak, Mutlu</creator><creator>Yakut, Tahsin</creator><creator>Ozsahin, Mustafa</creator><creator>Gurlevik, Zehra</creator><creator>Yanik, Mehmet Emin</creator><creator>Ucgun, Taner</creator><creator>Aliagaoglu, Cihangir</creator><creator>Yaykasli, Kursat Oguz</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201401</creationdate><title>Does MBL2 codon 54 polymorphism play a role in the pathogenesis of psoriasis?</title><author>Turan, Hakan ; Karkucak, Mutlu ; Yakut, Tahsin ; Ozsahin, Mustafa ; Gurlevik, Zehra ; Yanik, Mehmet Emin ; Ucgun, Taner ; Aliagaoglu, Cihangir ; Yaykasli, Kursat Oguz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3567-e881e6961f3a70fb7038dbea19f2e3f58f1c033aff68690598ca3042e8d0b7d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Codon - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Mannose-Binding Lectin - genetics</topic><topic>Middle Aged</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Psoriasis - etiology</topic><topic>Psoriasis - genetics</topic><topic>Turkey</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turan, Hakan</creatorcontrib><creatorcontrib>Karkucak, Mutlu</creatorcontrib><creatorcontrib>Yakut, Tahsin</creatorcontrib><creatorcontrib>Ozsahin, Mustafa</creatorcontrib><creatorcontrib>Gurlevik, Zehra</creatorcontrib><creatorcontrib>Yanik, Mehmet Emin</creatorcontrib><creatorcontrib>Ucgun, Taner</creatorcontrib><creatorcontrib>Aliagaoglu, Cihangir</creatorcontrib><creatorcontrib>Yaykasli, Kursat Oguz</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Turan, Hakan</au><au>Karkucak, Mutlu</au><au>Yakut, Tahsin</au><au>Ozsahin, Mustafa</au><au>Gurlevik, Zehra</au><au>Yanik, Mehmet Emin</au><au>Ucgun, Taner</au><au>Aliagaoglu, Cihangir</au><au>Yaykasli, Kursat Oguz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does MBL2 codon 54 polymorphism play a role in the pathogenesis of psoriasis?</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2014-01</date><risdate>2014</risdate><volume>53</volume><issue>1</issue><spage>34</spage><epage>38</epage><pages>34-38</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><abstract>Background  Psoriasis is a T cell‐mediated immune disease in which various cytokines, primarily tumor necrosis factor‐α (TNF‐α), are complexly involved. Mannose‐binding lectin (MBL) gene polymorphisms decrease MBL serum levels, thereby increasing the synthesis of proinflammatory cytokines such as TNF‐α. Objectives  This trial was designed to evaluate the role of the MBL2 codon 54 polymorphism in the pathogenesis of psoriasis. Methods  Fifty patients diagnosed with psoriasis vulgaris and 53 healthy subjects were included in the trial. The polymerase chain reaction–restriction fragment length polymorphism (PCR‐RFLP) method was applied to determine the MBL2 codon 54 polymorphism. Genotypes were determined according to the bands formed in agarose electrophoresis gels. For the statistical analysis, the level of significance was set at P &lt; 0.05. Results  A total of 33 (66.0%) of the 50 psoriasis patients were detected to have A/A genotype and 17 (34.0%) had B/B genotype. Of the control subjects, 44 (83.0%) had A/A genotype and nine (17.0%) had B/B genotype. There was a statistically significant difference between the groups (P = 0.047). The analysis of allele frequencies revealed A allele prevalences to be 79 (79.0%) and 95 (89.6%), and B allele prevalences to be 21 (21.0%) and 11 (10.4%), in the patient and control groups, respectively. A statistically significant difference between allele frequencies was detected (P = 0.031). Conclusions  This study suggests that the MBL2 codon 54 polymorphism may have an association with psoriasis in the Turkish population.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>23113841</pmid><doi>10.1111/j.1365-4632.2012.5657.x</doi><tpages>5</tpages></addata></record>
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source Wiley-Blackwell Read & Publish Collection
subjects Adult
Codon - genetics
Female
Gene Frequency
Genotype
Humans
Male
Mannose-Binding Lectin - genetics
Middle Aged
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Psoriasis - etiology
Psoriasis - genetics
Turkey
Young Adult
title Does MBL2 codon 54 polymorphism play a role in the pathogenesis of psoriasis?
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