Necrolytic acral erythema

Necrolytic acral erythema is a rare, cutaneous manifestation of hepatitis C virus infection that is characterized by erythematous, violaceous or dusky papules, blisters, and/or erosions in the early stages and by well-demarcated, hyperkeratotic, targetoid plaques with a peripheral rim of macular ery...

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Bibliographic Details
Published in:Dermatology online journal 2013-12, Vol.19 (12), p.20709-20709
Main Authors: Yost, John Montgomery, Boyd, Kevin P, Patel, Rishi R, Ramachandran, Sarika, Franks, Jr, Andrew G
Format: Article
Language:English
Subjects:
Antiviral Agents - therapeutic use
Erythema - complications
Erythema - drug therapy
Erythema - pathology
Female
Foot - pathology
Hepatitis C - complications
Hepatitis C - drug therapy
Hepatitis C - pathology
Humans
Middle Aged
Necrosis - complications
Necrosis - drug therapy
Necrosis - pathology
Skin Diseases - complications
Skin Diseases - drug therapy
Skin Diseases - pathology
Zinc - deficiency
Zinc - therapeutic use
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Description
Summary:Necrolytic acral erythema is a rare, cutaneous manifestation of hepatitis C virus infection that is characterized by erythematous, violaceous or dusky papules, blisters, and/or erosions in the early stages and by well-demarcated, hyperkeratotic, targetoid plaques with a peripheral rim of macular erythema, secondary lichenification and hyperpigmentation, and overlying fine micaceous or necrotic-appearing scale in the later stages. Because most topical modalities prove ineffective, treatment of the underlying viral infection or therapeutic zinc supplementation are required for clinical improvement.
ISSN:1087-2108
1087-2108
DOI:10.5070/D31912020709