Adrenal Diseases During Pregnancy: Pathophysiology, Diagnosis and Management Strategies

Abstract Adrenal diseases—including disorders such as Cushing's syndrome, Addison's disease, pheochromocytoma, primary hyperaldosteronism and congenital adrenal hyperplasia—are relatively rare in pregnancy, but a timely diagnosis and proper treatment are critical because these disorders ca...

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Bibliographic Details
Published in:The American journal of the medical sciences 2014-01, Vol.347 (1), p.64-73
Main Authors: Kamoun, Mahdi, MD, Mnif, Mouna F., PhD, Charfi, Nadia, PhD, Kacem, Faten H., MD, Naceur, Basma B., MD, Mnif, Fatma, PhD, Dammak, Mohamed, MD, Rekik, Nabila, PhD, Abid, Mohamed, PhD
Format: Article
Language:English
Subjects:
Addison Disease - diagnosis
Addison Disease - physiopathology
Addison Disease - therapy
Adrenal Gland Diseases - diagnosis
Adrenal Gland Diseases - physiopathology
Adrenal Gland Diseases - therapy
Adrenal Gland Neoplasms - diagnosis
Adrenal Gland Neoplasms - physiopathology
Adrenal Gland Neoplasms - therapy
Adrenal insufficiency
Congenital adrenal hyperplasia
Cushing Syndrome - diagnosis
Cushing Syndrome - physiopathology
Cushing Syndrome - therapy
Cushing's syndrome
Disease Management
Female
Humans
Hypothalamo-Hypophyseal System - physiopathology
Internal Medicine
Pheochromocytoma
Pheochromocytoma - diagnosis
Pheochromocytoma - physiopathology
Pheochromocytoma - therapy
Pituitary-Adrenal System - physiopathology
Pregnancy
Pregnancy adrenal disease
Pregnancy Complications - diagnosis
Pregnancy Complications - physiopathology
Pregnancy Complications - therapy
Primary hyperaldosteronism
Renin-Angiotensin System - physiology
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Summary:Abstract Adrenal diseases—including disorders such as Cushing's syndrome, Addison's disease, pheochromocytoma, primary hyperaldosteronism and congenital adrenal hyperplasia—are relatively rare in pregnancy, but a timely diagnosis and proper treatment are critical because these disorders can cause maternal and fetal morbidity and mortality. Making the diagnosis of adrenal disorders in pregnancy is challenging as symptoms associated with pregnancy are also seen in adrenal diseases. in addition, pregnancy is marked by several endocrine changes, including activation of the renin-angiotensin-aldosterone system and the hypothalamic-pituitary-adrenal axis. The aim of this article was to review the pathophysiology, clinical manifestation, diagnosis and management of various adrenal disorders during pregnancy.
ISSN:0002-9629
1538-2990
DOI:10.1097/MAJ.0b013e31828aaeee