Synthesis and Antioxidant Activity of Bis and Tris Heterocycles

A variety of bis heterocycles, oxazolyl/thiazolyl/imidazolyl oxadiazoles having a styryl sulfonylmethyl group at the 5‐position of oxadiazole and tris heterocycles having a pyrrolyl/pyrazolyl sulfonylmethyl group at the 5‐position of oxadiazole were prepared adopting simple and versatile synthetic m...

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Bibliographic Details
Published in:Archiv der Pharmazie (Weinheim) 2014-01, Vol.347 (1), p.54-67
Main Authors: Mahaboob Basha, Nabhubygari, Seenaiah, Dandu, Padmaja, Adivireddy, Padmavathi, Venkatapuram, Bhargav, Desaraju Suresh, Vijaya, Tartte
Format: Article
Language:English
Subjects:
1,3,4‐Oxadiazoles
4-Oxadiazoles
Antioxidant activity
Antioxidants
Ascorbic Acid - pharmacology
Benzothiazoles - chemistry
Biphenyl Compounds - chemistry
Drug Design
Free Radical Scavengers - chemical synthesis
Free Radical Scavengers - pharmacology
Heterocyclic Compounds - chemical synthesis
Heterocyclic Compounds - pharmacology
Molecular Structure
Nitric Oxide - chemistry
Picrates - chemistry
Pyrazole
Pyrrole
Structure-Activity Relationship
Sulfonic Acids - chemistry
Vitamin C
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Summary:A variety of bis heterocycles, oxazolyl/thiazolyl/imidazolyl oxadiazoles having a styryl sulfonylmethyl group at the 5‐position of oxadiazole and tris heterocycles having a pyrrolyl/pyrazolyl sulfonylmethyl group at the 5‐position of oxadiazole were prepared adopting simple and versatile synthetic methodologies. All the compounds were screened for their antioxidant activities. Compound 5b displayed radical scavenging activity in all the three methods greater than the standard ascorbic acid, whereas compounds 8b and 14b showed activities equal to the standard ascorbic acid. A variety of bis heterocycles and tris heterocycles were prepared and screened for their antioxidant activities. Compound 5b displayed radical scavenging activity greater than the standard ascorbic acid whereas compounds 8b and 14b showed activities equal to ascorbic acid.
ISSN:0365-6233
1521-4184
DOI:10.1002/ardp.201300290