Epigenetic effects of natural polyphenols: A focus on SIRT1-mediated mechanisms

Polyphenols are a class of natural compounds widely distributed in fruits, vegetables, and plants. They have been reported to possess a wide range of activities in prevention and alleviation of various diseases like cancer, neuroinflammation, diabetes, and aging. Polyphenols are effective against ch...

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Bibliographic Details
Published in:Molecular nutrition & food research 2014-01, Vol.58 (1), p.22-32
Main Authors: Ayissi, Vincent B. Owona, Ebrahimi, Azadeh, Schluesenner, Hermann
Format: Article
Language:English
Subjects:
Adipogenesis - drug effects
Aging - drug effects
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Anticarcinogenic Agents - pharmacology
Biological and medical sciences
Diet
Epigenesis, Genetic - drug effects
Epigenetic
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Humans
Inflammation
Lipid Metabolism - drug effects
Natural polyphenols
Neoplasms - prevention & control
Neurodegenerative Diseases - prevention & control
Polyphenols - chemistry
Polyphenols - pharmacology
SIRT1
Sirtuin 1 - metabolism
Structure-Activity Relationship
Vegetables
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Polyphenols are a class of natural compounds widely distributed in fruits, vegetables, and plants. They have been reported to possess a wide range of activities in prevention and alleviation of various diseases like cancer, neuroinflammation, diabetes, and aging. Polyphenols are effective against chronic diseases and recent reports indicated strong epigenetic effects of polyphenols. Most of the studies investigating epigenetic effects of natural polyphenols have focused on their beneficial effects in cancer treatment. However, epigenetic defects have been demonstrated in many other diseases as well, and application of polyphenols to modulate the epigenome is becoming an interesting field of research. This review summarizes the effects of natural polyphenols in modulating epigenetic‐related enzymes as well as their effect in prevention and treatment of chronic diseases with a focus on SIRT1 modulation. We have also discussed the relation between the structure and function of epigenetic‐modifying polyphenols.
ISSN:1613-4125
1613-4133
DOI:10.1002/mnfr.201300195