Glomerular filtration rates in healthy Asians without kidney disease

Aim The Chronic Kidney Disease Collaboration – Epidemiology (CKD‐EPI) glomerular filtration rates (GFR) estimation equation is believed to estimate GFR more accurately in healthy people but this has not been validated in Asians. We studied the distribution of GFR in a multi‐ethnic Asian population w...

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Bibliographic Details
Published in:Nephrology (Carlton, Vic.) Vic.), 2014-02, Vol.19 (2), p.72-79
Main Authors: Teo, Boon Wee, Xu, Hui, Koh, Yun Yin, Li, Jialiang, Subramanian, Srinivas, Sinha, Arvind Kumar, Shuter, Borys, Toh, Qi Chun, Sethi, Sunil, Lee, Evan JC
Format: Article
Language:English
Subjects:
Adult
Asian Continental Ancestry Group
Asians
bias
creatinine
Creatinine - urine
ethnic group
Female
Glomerular Filtration Rate
Humans
Male
Middle Aged
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Summary:Aim The Chronic Kidney Disease Collaboration – Epidemiology (CKD‐EPI) glomerular filtration rates (GFR) estimation equation is believed to estimate GFR more accurately in healthy people but this has not been validated in Asians. We studied the distribution of GFR in a multi‐ethnic Asian population without CKD, and compared the performance of measures of GFR estimation, including the CKD‐EPI equation, Cockroft‐Gault equation, and 24‐hour urine creatinine clearances. Materials and Methods A total of 103 healthy volunteers without a history of kidney disease, hypertension, or diabetes underwent GFR measurement using 3‐sample plasma clearance of 99mTc‐DTPA. Cockroft‐Gault estimated GFR and 24‐hour urine creatinine clearances were normalized to body surface area. Results The mean measured GFR was 101 ± 15.8 mL/min per 1.73 m2 and was lowest in Indians (93 ± 12.3 mL/min per 1.73 m2; P 
ISSN:1320-5358
1440-1797
DOI:10.1111/nep.12182