The effect of Clostridium botulinum toxin type A injections on motor unit activity of the deep digital flexor muscle in healthy sound Royal Dutch sport horses

Therapeutic reduction of the activity of the deep digital flexor (DDF) muscle may play a role in treatment of laminitic horses. Clostridium botulinum toxin type A induces reduced muscle activity and has a spasmolytic effect in horses. In this study, the effectiveness of 200IU C. botulinum toxin type...

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Bibliographic Details
Published in:The veterinary journal (1997) 2013-12, Vol.198, p.e147-e151
Main Authors: Wijnberg, Inge D., Hardeman, Lotte C., van der Meij, Bram R., Veraa, Stefanie, Back, Willem, van der Kolk, Johannes H.
Format: Article
Language:English
Subjects:
action potentials
adults
Animals
botulinum toxin
Botulinum Toxins, Type A - pharmacology
Clostridium botulinum
Clostridium botulinum toxin type A
Deep digital flexor muscle
Electromyography
Electromyography - veterinary
Equine
Female
Forelimb
horses
Horses - physiology
laminitis
Muscle, Skeletal - drug effects
muscles
Neuromuscular Agents - pharmacology
parasympatholytics
Recruitment, Neurophysiological - drug effects
Recruitment, Neurophysiological - physiology
sports
ultrasonics
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Summary:Therapeutic reduction of the activity of the deep digital flexor (DDF) muscle may play a role in treatment of laminitic horses. Clostridium botulinum toxin type A induces reduced muscle activity and has a spasmolytic effect in horses. In this study, the effectiveness of 200IU C. botulinum toxin type A on reduction of DDF muscle activity was measured in seven healthy, sound, adult Royal Dutch sport horses. C. botulinum toxin type A was injected using ultrasound and electromyographic (EMG) guidance. The effectiveness was assessed by interference pattern analysis (IPA) and motor unit action potential (MUAP) analysis. All needle EMG MUAP variables, along with IPA amplitude/turn and turns/s, were significantly reduced after C. botulinum toxin type A injections. The strongest effect occurred within the first 3days after injection. The reduced muscle induced by C. botulinum toxin type A may have benefits in the treatment of horses with laminitis.
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2013.09.050