A straight neutrophil path to healthy aging?

In this issue of Blood, Sapey et al. report that the human polymorphonuclear neutrophil leukocyte (or neutrophil) undergoes an age-related loss of its ability to migrate up chemotactic gradients, a functional defect that seems causally related to alterations in the polyphosphoinositide pathway.

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Bibliographic Details
Published in:Blood 2014-01, Vol.123 (2), p.154-156
Main Authors: Naccache, Paul H., Lefebvre, Julie S.
Format: Article
Language:English
Subjects:
Aging - immunology
Chemotaxis, Leukocyte - immunology
Humans
Neutrophils - immunology
Neutrophils - metabolism
Phosphoinositide-3 Kinase Inhibitors
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Description
Summary:In this issue of Blood, Sapey et al. report that the human polymorphonuclear neutrophil leukocyte (or neutrophil) undergoes an age-related loss of its ability to migrate up chemotactic gradients, a functional defect that seems causally related to alterations in the polyphosphoinositide pathway.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2013-11-538256