Oxidative stress and antioxidant enzyme activity in South Indian male smokers with chronic obstructive pulmonary disease

• Published in: Respirology (Carlton, Vic.) Vic.), 2013-10, Vol.18 (7), p.1069-1075
• Main Authors: Arja, Cholendra, Surapaneni, Krishna Mohan, Raya, Premanand, Adimoolam, Chandrasekar, Balisetty, Badhareenadhudu, Kanala, Kodanda Reddy
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; antioxidant; Antioxidants - metabolism; Case-Control Studies; Catalase - blood; chronic obstructive pulmonary disease; Glutathione - blood; Glutathione Peroxidase - blood; Glutathione Transferase - blood; Humans; India; Male; Malondialdehyde - blood; Middle Aged; oxidant; Oxidative Stress - physiology; Pulmonary Disease, Chronic Obstructive - etiology; Pulmonary Disease, Chronic Obstructive - metabolism; Pulmonary Disease, Chronic Obstructive - physiopathology; smoking; Smoking - adverse effects; spirometry; Superoxide Dismutase - blood
• ISSN: 1323-7799; 1440-1843
• DOI: 10.1111/resp.12118

Background and objective Oxidative stress resulting from tobacco smoking has been suggested to play a role in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of the present study was to evaluate the oxidant and antioxidant levels in smokers with and without COPD. Methods Two hundred thirty‐six patients with COPD and 150 smokers with no respiratory problems were selected. COPD diagnosis and staging was done based on the Global Initiative for Chronic Obstructive Lung Disease criteria. Plasma malondialdehyde (MDA) and erythrocyte glutathione (GSH) concentrations and superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione‐s‐transferase (GST) activities were assessed. Results COPD patients had higher levels of MDA and lower levels of antioxidants when compared with controls (P