Neurobiology of suicide: do biomarkers exist?

Clinical risk factors have a low predictive value on suicide. This may explain the increasing interest in potential neurobiological correlates and specific heritable markers of suicide vulnerability. This review aims to present the current neurobiological findings that have been shown to be implicat...

Full description

Saved in:
Bibliographic Details
Published in:International journal of legal medicine 2014, Vol.128 (1), p.73-82
Main Authors: Costanza, Alessandra, D’Orta, Isabella, Perroud, Nader, Burkhardt, Sandra, Malafosse, Alain, Mangin, Patrice, La Harpe, Romano
Format: Article
Language:English
Subjects:
Behavior
Biomarkers
Biomarkers - blood
Brain - physiopathology
Brain-Derived Neurotrophic Factor - blood
Brain-Derived Neurotrophic Factor - genetics
Epigenetics
Forensic Medicine
Genetic Association Studies
Genetic Markers - genetics
Humans
Medical Law
Medicine
Medicine & Public Health
Murders & murder attempts
Nerve Growth Factors - blood
Neurobiology
Neuropathology
Neurosciences
Neurotransmitter Agents - blood
Polyamines
Polyamines - blood
Polymorphism, Genetic - genetics
Predictive Value of Tests
Review Article
Risk Factors
Serotonin
Serotonin Plasma Membrane Transport Proteins
Suicide - legislation & jurisprudence
Suicide - psychology
Suicides & suicide attempts
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c415t-a30991376adbaf6738139e2d62f8ac836f2bcf0f633dbf21b9e2f82e9c40c94d3
cites cdi_FETCH-LOGICAL-c415t-a30991376adbaf6738139e2d62f8ac836f2bcf0f633dbf21b9e2f82e9c40c94d3
container_end_page 82
container_issue 1
container_start_page 73
container_title International journal of legal medicine
container_volume 128
creator Costanza, Alessandra
D’Orta, Isabella
Perroud, Nader
Burkhardt, Sandra
Malafosse, Alain
Mangin, Patrice
La Harpe, Romano
description Clinical risk factors have a low predictive value on suicide. This may explain the increasing interest in potential neurobiological correlates and specific heritable markers of suicide vulnerability. This review aims to present the current neurobiological findings that have been shown to be implicated in suicide completers and to discuss how postmortem studies may be useful in characterizing these individuals. Data on the role of the main neurobiological systems in suicidality, such as the neurotransmitter families, hypothalamic–pituitary–adrenal axis, neurotrophic factors, and polyamines, are exposed at the different biochemical, genetic, and epigenetic levels. Some neuroanatomic and neuropathological aspects as well as their in vivo morphological and functional neuroimaging correlates are also described. Except for the serotoninergic system, particularly with respect to the polymorphism of the gene coding for the serotonin transporter (5-HTTLPR) and brain-derived neurotrophic factor, data did not converge to produce a univocal consensus. The possible limitations of currently published studies are discussed, as well as the scope for long-term prospective studies.
doi_str_mv 10.1007/s00414-013-0835-6
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1490782280</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3170205631</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-a30991376adbaf6738139e2d62f8ac836f2bcf0f633dbf21b9e2f82e9c40c94d3</originalsourceid><addsrcrecordid>eNp1kMtKAzEUhoMotlYfwI0MuHETPblMLm5EijcoutF1mMkkZWrb1KQD9u1NmSoiuErI-c5_Tj6ETglcEgB5lQA44RgIw6BYicUeGhLOJCalFvtoCDrftaJygI5SmgEQKWR5iAaUcQaEkyHCz66LoW7DPEw3RfBF6lrbNu66aEKRnxdVfHcxFe6zTeubY3Tgq3lyJ7tzhN7u717Hj3jy8vA0vp1gy0m5xhUDrQmTomrqygvJFGHa0UZQryqrmPC0th68YKypPSV1LnpFnbYcrOYNG6GLPncVw0fn0tos2mTdfF4tXeiSIVyDVJQqyOj5H3QWurjM22VKsrwJCJUp0lM2hpSi82YV2_y3jSFgti5N79Jkl2br0ojcc7ZL7uqFa346vuVlgPZAyqXl1MVfo_9N_QJDMny7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1473309068</pqid></control><display><type>article</type><title>Neurobiology of suicide: do biomarkers exist?</title><source>Criminology Collection</source><source>Social Science Premium Collection</source><source>Springer Nature</source><creator>Costanza, Alessandra ; D’Orta, Isabella ; Perroud, Nader ; Burkhardt, Sandra ; Malafosse, Alain ; Mangin, Patrice ; La Harpe, Romano</creator><creatorcontrib>Costanza, Alessandra ; D’Orta, Isabella ; Perroud, Nader ; Burkhardt, Sandra ; Malafosse, Alain ; Mangin, Patrice ; La Harpe, Romano</creatorcontrib><description>Clinical risk factors have a low predictive value on suicide. This may explain the increasing interest in potential neurobiological correlates and specific heritable markers of suicide vulnerability. This review aims to present the current neurobiological findings that have been shown to be implicated in suicide completers and to discuss how postmortem studies may be useful in characterizing these individuals. Data on the role of the main neurobiological systems in suicidality, such as the neurotransmitter families, hypothalamic–pituitary–adrenal axis, neurotrophic factors, and polyamines, are exposed at the different biochemical, genetic, and epigenetic levels. Some neuroanatomic and neuropathological aspects as well as their in vivo morphological and functional neuroimaging correlates are also described. Except for the serotoninergic system, particularly with respect to the polymorphism of the gene coding for the serotonin transporter (5-HTTLPR) and brain-derived neurotrophic factor, data did not converge to produce a univocal consensus. The possible limitations of currently published studies are discussed, as well as the scope for long-term prospective studies.</description><identifier>ISSN: 0937-9827</identifier><identifier>EISSN: 1437-1596</identifier><identifier>DOI: 10.1007/s00414-013-0835-6</identifier><identifier>PMID: 23430141</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Behavior ; Biomarkers ; Biomarkers - blood ; Brain - physiopathology ; Brain-Derived Neurotrophic Factor - blood ; Brain-Derived Neurotrophic Factor - genetics ; Epigenetics ; Forensic Medicine ; Genetic Association Studies ; Genetic Markers - genetics ; Humans ; Medical Law ; Medicine ; Medicine &amp; Public Health ; Murders &amp; murder attempts ; Nerve Growth Factors - blood ; Neurobiology ; Neuropathology ; Neurosciences ; Neurotransmitter Agents - blood ; Polyamines ; Polyamines - blood ; Polymorphism, Genetic - genetics ; Predictive Value of Tests ; Review Article ; Risk Factors ; Serotonin ; Serotonin Plasma Membrane Transport Proteins ; Suicide - legislation &amp; jurisprudence ; Suicide - psychology ; Suicides &amp; suicide attempts</subject><ispartof>International journal of legal medicine, 2014, Vol.128 (1), p.73-82</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-a30991376adbaf6738139e2d62f8ac836f2bcf0f633dbf21b9e2f82e9c40c94d3</citedby><cites>FETCH-LOGICAL-c415t-a30991376adbaf6738139e2d62f8ac836f2bcf0f633dbf21b9e2f82e9c40c94d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1473309068/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1473309068?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21374,21392,27922,27923,33609,33610,33767,33768,43731,43812,73991,74080</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23430141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Costanza, Alessandra</creatorcontrib><creatorcontrib>D’Orta, Isabella</creatorcontrib><creatorcontrib>Perroud, Nader</creatorcontrib><creatorcontrib>Burkhardt, Sandra</creatorcontrib><creatorcontrib>Malafosse, Alain</creatorcontrib><creatorcontrib>Mangin, Patrice</creatorcontrib><creatorcontrib>La Harpe, Romano</creatorcontrib><title>Neurobiology of suicide: do biomarkers exist?</title><title>International journal of legal medicine</title><addtitle>Int J Legal Med</addtitle><addtitle>Int J Legal Med</addtitle><description>Clinical risk factors have a low predictive value on suicide. This may explain the increasing interest in potential neurobiological correlates and specific heritable markers of suicide vulnerability. This review aims to present the current neurobiological findings that have been shown to be implicated in suicide completers and to discuss how postmortem studies may be useful in characterizing these individuals. Data on the role of the main neurobiological systems in suicidality, such as the neurotransmitter families, hypothalamic–pituitary–adrenal axis, neurotrophic factors, and polyamines, are exposed at the different biochemical, genetic, and epigenetic levels. Some neuroanatomic and neuropathological aspects as well as their in vivo morphological and functional neuroimaging correlates are also described. Except for the serotoninergic system, particularly with respect to the polymorphism of the gene coding for the serotonin transporter (5-HTTLPR) and brain-derived neurotrophic factor, data did not converge to produce a univocal consensus. The possible limitations of currently published studies are discussed, as well as the scope for long-term prospective studies.</description><subject>Behavior</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Brain - physiopathology</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Epigenetics</subject><subject>Forensic Medicine</subject><subject>Genetic Association Studies</subject><subject>Genetic Markers - genetics</subject><subject>Humans</subject><subject>Medical Law</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Murders &amp; murder attempts</subject><subject>Nerve Growth Factors - blood</subject><subject>Neurobiology</subject><subject>Neuropathology</subject><subject>Neurosciences</subject><subject>Neurotransmitter Agents - blood</subject><subject>Polyamines</subject><subject>Polyamines - blood</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Predictive Value of Tests</subject><subject>Review Article</subject><subject>Risk Factors</subject><subject>Serotonin</subject><subject>Serotonin Plasma Membrane Transport Proteins</subject><subject>Suicide - legislation &amp; jurisprudence</subject><subject>Suicide - psychology</subject><subject>Suicides &amp; suicide attempts</subject><issn>0937-9827</issn><issn>1437-1596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>BGRYB</sourceid><sourceid>M0O</sourceid><recordid>eNp1kMtKAzEUhoMotlYfwI0MuHETPblMLm5EijcoutF1mMkkZWrb1KQD9u1NmSoiuErI-c5_Tj6ETglcEgB5lQA44RgIw6BYicUeGhLOJCalFvtoCDrftaJygI5SmgEQKWR5iAaUcQaEkyHCz66LoW7DPEw3RfBF6lrbNu66aEKRnxdVfHcxFe6zTeubY3Tgq3lyJ7tzhN7u717Hj3jy8vA0vp1gy0m5xhUDrQmTomrqygvJFGHa0UZQryqrmPC0th68YKypPSV1LnpFnbYcrOYNG6GLPncVw0fn0tos2mTdfF4tXeiSIVyDVJQqyOj5H3QWurjM22VKsrwJCJUp0lM2hpSi82YV2_y3jSFgti5N79Jkl2br0ojcc7ZL7uqFa346vuVlgPZAyqXl1MVfo_9N_QJDMny7</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Costanza, Alessandra</creator><creator>D’Orta, Isabella</creator><creator>Perroud, Nader</creator><creator>Burkhardt, Sandra</creator><creator>Malafosse, Alain</creator><creator>Mangin, Patrice</creator><creator>La Harpe, Romano</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AM</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BGRYB</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>HCIFZ</scope><scope>K7.</scope><scope>K9.</scope><scope>L6V</scope><scope>M0O</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Neurobiology of suicide: do biomarkers exist?</title><author>Costanza, Alessandra ; D’Orta, Isabella ; Perroud, Nader ; Burkhardt, Sandra ; Malafosse, Alain ; Mangin, Patrice ; La Harpe, Romano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-a30991376adbaf6738139e2d62f8ac836f2bcf0f633dbf21b9e2f82e9c40c94d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Behavior</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Brain - physiopathology</topic><topic>Brain-Derived Neurotrophic Factor - blood</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Epigenetics</topic><topic>Forensic Medicine</topic><topic>Genetic Association Studies</topic><topic>Genetic Markers - genetics</topic><topic>Humans</topic><topic>Medical Law</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Murders &amp; murder attempts</topic><topic>Nerve Growth Factors - blood</topic><topic>Neurobiology</topic><topic>Neuropathology</topic><topic>Neurosciences</topic><topic>Neurotransmitter Agents - blood</topic><topic>Polyamines</topic><topic>Polyamines - blood</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Predictive Value of Tests</topic><topic>Review Article</topic><topic>Risk Factors</topic><topic>Serotonin</topic><topic>Serotonin Plasma Membrane Transport Proteins</topic><topic>Suicide - legislation &amp; jurisprudence</topic><topic>Suicide - psychology</topic><topic>Suicides &amp; suicide attempts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Costanza, Alessandra</creatorcontrib><creatorcontrib>D’Orta, Isabella</creatorcontrib><creatorcontrib>Perroud, Nader</creatorcontrib><creatorcontrib>Burkhardt, Sandra</creatorcontrib><creatorcontrib>Malafosse, Alain</creatorcontrib><creatorcontrib>Mangin, Patrice</creatorcontrib><creatorcontrib>La Harpe, Romano</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Criminal Justice Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Criminology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Criminal Justice Periodicals</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Engineering Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of legal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Costanza, Alessandra</au><au>D’Orta, Isabella</au><au>Perroud, Nader</au><au>Burkhardt, Sandra</au><au>Malafosse, Alain</au><au>Mangin, Patrice</au><au>La Harpe, Romano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurobiology of suicide: do biomarkers exist?</atitle><jtitle>International journal of legal medicine</jtitle><stitle>Int J Legal Med</stitle><addtitle>Int J Legal Med</addtitle><date>2014</date><risdate>2014</risdate><volume>128</volume><issue>1</issue><spage>73</spage><epage>82</epage><pages>73-82</pages><issn>0937-9827</issn><eissn>1437-1596</eissn><abstract>Clinical risk factors have a low predictive value on suicide. This may explain the increasing interest in potential neurobiological correlates and specific heritable markers of suicide vulnerability. This review aims to present the current neurobiological findings that have been shown to be implicated in suicide completers and to discuss how postmortem studies may be useful in characterizing these individuals. Data on the role of the main neurobiological systems in suicidality, such as the neurotransmitter families, hypothalamic–pituitary–adrenal axis, neurotrophic factors, and polyamines, are exposed at the different biochemical, genetic, and epigenetic levels. Some neuroanatomic and neuropathological aspects as well as their in vivo morphological and functional neuroimaging correlates are also described. Except for the serotoninergic system, particularly with respect to the polymorphism of the gene coding for the serotonin transporter (5-HTTLPR) and brain-derived neurotrophic factor, data did not converge to produce a univocal consensus. The possible limitations of currently published studies are discussed, as well as the scope for long-term prospective studies.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23430141</pmid><doi>10.1007/s00414-013-0835-6</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0937-9827
ispartof International journal of legal medicine, 2014, Vol.128 (1), p.73-82
issn 0937-9827
1437-1596
language eng
recordid cdi_proquest_miscellaneous_1490782280
source Criminology Collection; Social Science Premium Collection; Springer Nature
subjects Behavior
Biomarkers
Biomarkers - blood
Brain - physiopathology
Brain-Derived Neurotrophic Factor - blood
Brain-Derived Neurotrophic Factor - genetics
Epigenetics
Forensic Medicine
Genetic Association Studies
Genetic Markers - genetics
Humans
Medical Law
Medicine
Medicine & Public Health
Murders & murder attempts
Nerve Growth Factors - blood
Neurobiology
Neuropathology
Neurosciences
Neurotransmitter Agents - blood
Polyamines
Polyamines - blood
Polymorphism, Genetic - genetics
Predictive Value of Tests
Review Article
Risk Factors
Serotonin
Serotonin Plasma Membrane Transport Proteins
Suicide - legislation & jurisprudence
Suicide - psychology
Suicides & suicide attempts
title Neurobiology of suicide: do biomarkers exist?
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T10%3A32%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neurobiology%20of%20suicide:%20do%20biomarkers%20exist?&rft.jtitle=International%20journal%20of%20legal%20medicine&rft.au=Costanza,%20Alessandra&rft.date=2014&rft.volume=128&rft.issue=1&rft.spage=73&rft.epage=82&rft.pages=73-82&rft.issn=0937-9827&rft.eissn=1437-1596&rft_id=info:doi/10.1007/s00414-013-0835-6&rft_dat=%3Cproquest_cross%3E3170205631%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c415t-a30991376adbaf6738139e2d62f8ac836f2bcf0f633dbf21b9e2f82e9c40c94d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1473309068&rft_id=info:pmid/23430141&rfr_iscdi=true