Clinical usefulness of non-protein respiratory quotient measurement in non-alcoholic fatty liver disease

Aim Little is known about the effects of non‐alcoholic fatty liver disease (NAFLD) on energy metabolism, although this disease is associated with metabolic syndrome. We measured non‐protein respiratory quotient (npRQ) using indirect calorimetry, which reflects glucose oxidation, and compared this va...

Full description

Saved in:
Bibliographic Details
Published in:Hepatology research 2013-12, Vol.43 (12), p.1284-1294
Main Authors: Korenaga, Keiko, Korenaga, Masaaki, Teramoto, Fusako, Suzuki, Toshiko, Nishina, Sohji, Sasaki, Kyo, Nakashima, Yoshihiro, Tomiyama, Yasuyuki, Yoshioka, Naoko, Hara, Yuichi, Moriya, Takuya, Hino, Keisuke
Format: Article
Language:English
Subjects:
glucose intolerance
NAFLD
npRQ
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim Little is known about the effects of non‐alcoholic fatty liver disease (NAFLD) on energy metabolism, although this disease is associated with metabolic syndrome. We measured non‐protein respiratory quotient (npRQ) using indirect calorimetry, which reflects glucose oxidation, and compared this value with histological disease severity in NAFLD patients. Methods Subjects were 32 patients who were diagnosed with NAFLD histopathologically. Subjects underwent body composition analysis and indirect calorimetry, and npRQ was calculated. An oral glucose tolerance test was performed, and plasma glucose area under the curve (AUC glucose) was calculated. Results There were no differences in body mass index, body fat percentage or visceral fat area among fibrosis stage groups. As fibrosis progressed, npRQ significantly decreased (stage 0, 0.895 ± 0.068; stage 1, 0.869 ± 0.067; stage 2, 0.808 ± 0.046; stage 3, 0.798 ± 0.026; P 
ISSN:1386-6346
1872-034X
DOI:10.1111/hepr.12095