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Association of T-cell co-regulatory protein expression with clinical outcomes following radical cystectomy for urothelial carcinoma of the bladder
Abstract Purpose Expression of T-cell co-regulatory proteins has been associated with worse outcomes in patients with UCB. We aimed to confirm these findings. Materials and methods The study comprised tissue microarrays from 302 consecutive UCB patients treated with RC and lymphadenectomy between 19...
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| Published in: | European journal of surgical oncology 2014-01, Vol.40 (1), p.121-127 |
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| container_title | European journal of surgical oncology |
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| creator | Xylinas, E Robinson, B.D Kluth, L.A Volkmer, B.G Hautmann, R Küfer, R Zerbib, M Kwon, E Thompson, R.H Boorjian, S.A Shariat, S.F |
| description | Abstract Purpose Expression of T-cell co-regulatory proteins has been associated with worse outcomes in patients with UCB. We aimed to confirm these findings. Materials and methods The study comprised tissue microarrays from 302 consecutive UCB patients treated with RC and lymphadenectomy between 1988 and 2003, 117 matched lymph nodes, and 50 cases of adjacent normal urothelium controls, which were evaluated for B7-H1, B7-H3, and PD-1 protein expression by immunohistochemistry. Results B7-H3 and PD-1 expression were increased in cancers compared to adjacent normal urothelium (58.6% vs 6% and 65% vs 0%, respectively; both p values |
| doi_str_mv | 10.1016/j.ejso.2013.08.023 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1490898270</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0748798313007622</els_id><sourcerecordid>1490898270</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-b054cfe9dac2cc0fc575e7e913d3e1181aaed61d98fc5bb09cbde30bcf77bccd3</originalsourceid><addsrcrecordid>eNp9UsFu1TAQjBCIPgo_wAH5yCVhbSfPiYSQqooCUiUOlLPlrDetQxI_7KQlv8EX1-G1HDhwsuyZHWtmNstecyg48P27vqA--kIAlwXUBQj5JNvxSopc8Eo9zXagyjpXTS1Pshcx9gDQSNU8z05Eyct0g132-yxGj87Mzk_Md-wqRxoGhj4PdL0MZvZhZYfgZ3ITo1-HQDFu1Ds33zAc3OTQDMwvM_qRIuv8MPg7N12zYOwfCNc4E85-XBMY2JKkbmhwG2ICusmPZvs3PbJ2MNZSeJk968wQ6dXDeZp9v_h4df45v_z66cv52WWOJedz3kJVYkeNNSgQocNKVaSo4dJK4rzmxpDdc9vUCWpbaLC1JKHFTqkW0crT7O1RN9n7uVCc9eji5t5M5JeoedlA3dRCQaKKIxWDjzFQpw_BjSasmoPeutC93rrQWxcaap26SENvHvSXdiT7d-Qx_ER4fyRQcnnrKOiIjiYk60KKTFvv_q__4Z_xxz5-0Eqx90uYUn6a6yg06G_bNmzLwCWA2gsh7wEBBLVJ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1490898270</pqid></control><display><type>article</type><title>Association of T-cell co-regulatory protein expression with clinical outcomes following radical cystectomy for urothelial carcinoma of the bladder</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Xylinas, E ; Robinson, B.D ; Kluth, L.A ; Volkmer, B.G ; Hautmann, R ; Küfer, R ; Zerbib, M ; Kwon, E ; Thompson, R.H ; Boorjian, S.A ; Shariat, S.F</creator><creatorcontrib>Xylinas, E ; Robinson, B.D ; Kluth, L.A ; Volkmer, B.G ; Hautmann, R ; Küfer, R ; Zerbib, M ; Kwon, E ; Thompson, R.H ; Boorjian, S.A ; Shariat, S.F</creatorcontrib><description>Abstract Purpose Expression of T-cell co-regulatory proteins has been associated with worse outcomes in patients with UCB. We aimed to confirm these findings. Materials and methods The study comprised tissue microarrays from 302 consecutive UCB patients treated with RC and lymphadenectomy between 1988 and 2003, 117 matched lymph nodes, and 50 cases of adjacent normal urothelium controls, which were evaluated for B7-H1, B7-H3, and PD-1 protein expression by immunohistochemistry. Results B7-H3 and PD-1 expression were increased in cancers compared to adjacent normal urothelium (58.6% vs 6% and 65% vs 0%, respectively; both p values < 0.001). Meanwhile, B7-H1 was expressed in 25% of cancers ( n = 76). Expression of B7-H3, B7-H1, and PD-1 were highly correlated between the primary tumors and metastatic nodes, with concordance rates of 90%, 86%, and 78% for B7H3, B7H1 and PD-1, respectively. Expression was not associated with clinicopathologic features, disease recurrence, cancer-specific or overall mortality. However, for the subgroup of patients with organ-confined disease ( n = 96), B7-H1 expression was associated with an increased risk of overall mortality ( p = 0.02) on univariate and trended toward an association on multivariate analyses ( p = 0.06). Conclusions B7-H1, B7-H3 and PD-1 are altered in a large proportion of UCB. B7-H1 and PD-1 expression are differentially upregulated in cancer versus normal urothelium. High correlation between expression in LN and expression in RC specimens was observed. While expression was not associated with clinicopathologic features or standard outcomes in all patients, B7-H1 expression predicted overall mortality after RC in the subset of patients with organ-confined UCB.</description><identifier>ISSN: 0748-7983</identifier><identifier>EISSN: 1532-2157</identifier><identifier>DOI: 10.1016/j.ejso.2013.08.023</identifier><identifier>PMID: 24140000</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Aged ; B7 Antigens - analysis ; B7-H1 Antigen - analysis ; Biomarkers, Tumor - analysis ; Bladder cancer ; Carcinoma, Transitional Cell - chemistry ; Carcinoma, Transitional Cell - metabolism ; Carcinoma, Transitional Cell - mortality ; Carcinoma, Transitional Cell - surgery ; Case-Control Studies ; Cystectomy - methods ; Female ; Gene Expression Regulation, Neoplastic ; Hematology, Oncology and Palliative Medicine ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Lymph Node Excision ; Male ; Middle Aged ; Outcomes ; Predictive Value of Tests ; Prognosis ; Programmed Cell Death 1 Receptor - analysis ; Surgery ; Survival ; T-cell regulators ; T-Lymphocytes, Regulatory - metabolism ; Tissue Array Analysis ; Urinary Bladder Neoplasms - chemistry ; Urinary Bladder Neoplasms - metabolism ; Urinary Bladder Neoplasms - mortality ; Urinary Bladder Neoplasms - surgery</subject><ispartof>European journal of surgical oncology, 2014-01, Vol.40 (1), p.121-127</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-b054cfe9dac2cc0fc575e7e913d3e1181aaed61d98fc5bb09cbde30bcf77bccd3</citedby><cites>FETCH-LOGICAL-c411t-b054cfe9dac2cc0fc575e7e913d3e1181aaed61d98fc5bb09cbde30bcf77bccd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24140000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xylinas, E</creatorcontrib><creatorcontrib>Robinson, B.D</creatorcontrib><creatorcontrib>Kluth, L.A</creatorcontrib><creatorcontrib>Volkmer, B.G</creatorcontrib><creatorcontrib>Hautmann, R</creatorcontrib><creatorcontrib>Küfer, R</creatorcontrib><creatorcontrib>Zerbib, M</creatorcontrib><creatorcontrib>Kwon, E</creatorcontrib><creatorcontrib>Thompson, R.H</creatorcontrib><creatorcontrib>Boorjian, S.A</creatorcontrib><creatorcontrib>Shariat, S.F</creatorcontrib><title>Association of T-cell co-regulatory protein expression with clinical outcomes following radical cystectomy for urothelial carcinoma of the bladder</title><title>European journal of surgical oncology</title><addtitle>Eur J Surg Oncol</addtitle><description>Abstract Purpose Expression of T-cell co-regulatory proteins has been associated with worse outcomes in patients with UCB. We aimed to confirm these findings. Materials and methods The study comprised tissue microarrays from 302 consecutive UCB patients treated with RC and lymphadenectomy between 1988 and 2003, 117 matched lymph nodes, and 50 cases of adjacent normal urothelium controls, which were evaluated for B7-H1, B7-H3, and PD-1 protein expression by immunohistochemistry. Results B7-H3 and PD-1 expression were increased in cancers compared to adjacent normal urothelium (58.6% vs 6% and 65% vs 0%, respectively; both p values < 0.001). Meanwhile, B7-H1 was expressed in 25% of cancers ( n = 76). Expression of B7-H3, B7-H1, and PD-1 were highly correlated between the primary tumors and metastatic nodes, with concordance rates of 90%, 86%, and 78% for B7H3, B7H1 and PD-1, respectively. Expression was not associated with clinicopathologic features, disease recurrence, cancer-specific or overall mortality. However, for the subgroup of patients with organ-confined disease ( n = 96), B7-H1 expression was associated with an increased risk of overall mortality ( p = 0.02) on univariate and trended toward an association on multivariate analyses ( p = 0.06). Conclusions B7-H1, B7-H3 and PD-1 are altered in a large proportion of UCB. B7-H1 and PD-1 expression are differentially upregulated in cancer versus normal urothelium. High correlation between expression in LN and expression in RC specimens was observed. While expression was not associated with clinicopathologic features or standard outcomes in all patients, B7-H1 expression predicted overall mortality after RC in the subset of patients with organ-confined UCB.</description><subject>Adult</subject><subject>Aged</subject><subject>B7 Antigens - analysis</subject><subject>B7-H1 Antigen - analysis</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Bladder cancer</subject><subject>Carcinoma, Transitional Cell - chemistry</subject><subject>Carcinoma, Transitional Cell - metabolism</subject><subject>Carcinoma, Transitional Cell - mortality</subject><subject>Carcinoma, Transitional Cell - surgery</subject><subject>Case-Control Studies</subject><subject>Cystectomy - methods</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymph Node Excision</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Outcomes</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Programmed Cell Death 1 Receptor - analysis</subject><subject>Surgery</subject><subject>Survival</subject><subject>T-cell regulators</subject><subject>T-Lymphocytes, Regulatory - metabolism</subject><subject>Tissue Array Analysis</subject><subject>Urinary Bladder Neoplasms - chemistry</subject><subject>Urinary Bladder Neoplasms - metabolism</subject><subject>Urinary Bladder Neoplasms - mortality</subject><subject>Urinary Bladder Neoplasms - surgery</subject><issn>0748-7983</issn><issn>1532-2157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9UsFu1TAQjBCIPgo_wAH5yCVhbSfPiYSQqooCUiUOlLPlrDetQxI_7KQlv8EX1-G1HDhwsuyZHWtmNstecyg48P27vqA--kIAlwXUBQj5JNvxSopc8Eo9zXagyjpXTS1Pshcx9gDQSNU8z05Eyct0g132-yxGj87Mzk_Md-wqRxoGhj4PdL0MZvZhZYfgZ3ITo1-HQDFu1Ds33zAc3OTQDMwvM_qRIuv8MPg7N12zYOwfCNc4E85-XBMY2JKkbmhwG2ICusmPZvs3PbJ2MNZSeJk968wQ6dXDeZp9v_h4df45v_z66cv52WWOJedz3kJVYkeNNSgQocNKVaSo4dJK4rzmxpDdc9vUCWpbaLC1JKHFTqkW0crT7O1RN9n7uVCc9eji5t5M5JeoedlA3dRCQaKKIxWDjzFQpw_BjSasmoPeutC93rrQWxcaap26SENvHvSXdiT7d-Qx_ER4fyRQcnnrKOiIjiYk60KKTFvv_q__4Z_xxz5-0Eqx90uYUn6a6yg06G_bNmzLwCWA2gsh7wEBBLVJ</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Xylinas, E</creator><creator>Robinson, B.D</creator><creator>Kluth, L.A</creator><creator>Volkmer, B.G</creator><creator>Hautmann, R</creator><creator>Küfer, R</creator><creator>Zerbib, M</creator><creator>Kwon, E</creator><creator>Thompson, R.H</creator><creator>Boorjian, S.A</creator><creator>Shariat, S.F</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140101</creationdate><title>Association of T-cell co-regulatory protein expression with clinical outcomes following radical cystectomy for urothelial carcinoma of the bladder</title><author>Xylinas, E ; Robinson, B.D ; Kluth, L.A ; Volkmer, B.G ; Hautmann, R ; Küfer, R ; Zerbib, M ; Kwon, E ; Thompson, R.H ; Boorjian, S.A ; Shariat, S.F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-b054cfe9dac2cc0fc575e7e913d3e1181aaed61d98fc5bb09cbde30bcf77bccd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>B7 Antigens - analysis</topic><topic>B7-H1 Antigen - analysis</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Bladder cancer</topic><topic>Carcinoma, Transitional Cell - chemistry</topic><topic>Carcinoma, Transitional Cell - metabolism</topic><topic>Carcinoma, Transitional Cell - mortality</topic><topic>Carcinoma, Transitional Cell - surgery</topic><topic>Case-Control Studies</topic><topic>Cystectomy - methods</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kaplan-Meier Estimate</topic><topic>Lymph Node Excision</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Outcomes</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Programmed Cell Death 1 Receptor - analysis</topic><topic>Surgery</topic><topic>Survival</topic><topic>T-cell regulators</topic><topic>T-Lymphocytes, Regulatory - metabolism</topic><topic>Tissue Array Analysis</topic><topic>Urinary Bladder Neoplasms - chemistry</topic><topic>Urinary Bladder Neoplasms - metabolism</topic><topic>Urinary Bladder Neoplasms - mortality</topic><topic>Urinary Bladder Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xylinas, E</creatorcontrib><creatorcontrib>Robinson, B.D</creatorcontrib><creatorcontrib>Kluth, L.A</creatorcontrib><creatorcontrib>Volkmer, B.G</creatorcontrib><creatorcontrib>Hautmann, R</creatorcontrib><creatorcontrib>Küfer, R</creatorcontrib><creatorcontrib>Zerbib, M</creatorcontrib><creatorcontrib>Kwon, E</creatorcontrib><creatorcontrib>Thompson, R.H</creatorcontrib><creatorcontrib>Boorjian, S.A</creatorcontrib><creatorcontrib>Shariat, S.F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xylinas, E</au><au>Robinson, B.D</au><au>Kluth, L.A</au><au>Volkmer, B.G</au><au>Hautmann, R</au><au>Küfer, R</au><au>Zerbib, M</au><au>Kwon, E</au><au>Thompson, R.H</au><au>Boorjian, S.A</au><au>Shariat, S.F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of T-cell co-regulatory protein expression with clinical outcomes following radical cystectomy for urothelial carcinoma of the bladder</atitle><jtitle>European journal of surgical oncology</jtitle><addtitle>Eur J Surg Oncol</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>40</volume><issue>1</issue><spage>121</spage><epage>127</epage><pages>121-127</pages><issn>0748-7983</issn><eissn>1532-2157</eissn><abstract>Abstract Purpose Expression of T-cell co-regulatory proteins has been associated with worse outcomes in patients with UCB. We aimed to confirm these findings. Materials and methods The study comprised tissue microarrays from 302 consecutive UCB patients treated with RC and lymphadenectomy between 1988 and 2003, 117 matched lymph nodes, and 50 cases of adjacent normal urothelium controls, which were evaluated for B7-H1, B7-H3, and PD-1 protein expression by immunohistochemistry. Results B7-H3 and PD-1 expression were increased in cancers compared to adjacent normal urothelium (58.6% vs 6% and 65% vs 0%, respectively; both p values < 0.001). Meanwhile, B7-H1 was expressed in 25% of cancers ( n = 76). Expression of B7-H3, B7-H1, and PD-1 were highly correlated between the primary tumors and metastatic nodes, with concordance rates of 90%, 86%, and 78% for B7H3, B7H1 and PD-1, respectively. Expression was not associated with clinicopathologic features, disease recurrence, cancer-specific or overall mortality. However, for the subgroup of patients with organ-confined disease ( n = 96), B7-H1 expression was associated with an increased risk of overall mortality ( p = 0.02) on univariate and trended toward an association on multivariate analyses ( p = 0.06). Conclusions B7-H1, B7-H3 and PD-1 are altered in a large proportion of UCB. B7-H1 and PD-1 expression are differentially upregulated in cancer versus normal urothelium. High correlation between expression in LN and expression in RC specimens was observed. While expression was not associated with clinicopathologic features or standard outcomes in all patients, B7-H1 expression predicted overall mortality after RC in the subset of patients with organ-confined UCB.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>24140000</pmid><doi>10.1016/j.ejso.2013.08.023</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged B7 Antigens - analysis B7-H1 Antigen - analysis Biomarkers, Tumor - analysis Bladder cancer Carcinoma, Transitional Cell - chemistry Carcinoma, Transitional Cell - metabolism Carcinoma, Transitional Cell - mortality Carcinoma, Transitional Cell - surgery Case-Control Studies Cystectomy - methods Female Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Kaplan-Meier Estimate Lymph Node Excision Male Middle Aged Outcomes Predictive Value of Tests Prognosis Programmed Cell Death 1 Receptor - analysis Surgery Survival T-cell regulators T-Lymphocytes, Regulatory - metabolism Tissue Array Analysis Urinary Bladder Neoplasms - chemistry Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - mortality Urinary Bladder Neoplasms - surgery |
| title | Association of T-cell co-regulatory protein expression with clinical outcomes following radical cystectomy for urothelial carcinoma of the bladder |
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