Mucoadhesivity and release properties of quaternary ammonium–chitosan conjugates and their nanoparticulate supramolecular aggregates: An NMR investigation

Selective relaxation rate measurements effectively proved the affinity of dexamethasone 21-phosphate disodium salt for quaternary ammonium–chitosan conjugates, their thiolated derivatives and the corresponding nanostructured aggregates. Affinity was also probed by dynamic dialysis. The release profi...

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Bibliographic Details
Published in:International journal of pharmaceutics 2014-01, Vol.461 (1-2), p.489-494
Main Authors: Uccello-Barretta, Gloria, Balzano, Federica, Aiello, Federica, Senatore, Alessandro, Fabiano, Angela, Zambito, Ylenia
Format: Article
Language:English
Subjects:
Adhesiveness
Animals
Cattle
Chitosan - chemistry
Chitosan conjugates
Dexamethasone - analogs & derivatives
Dexamethasone - chemistry
Dialysis
Dynamic dialysis
Interrupted dialysis
Magnetic Resonance Spectroscopy - methods
Mucins - metabolism
Nanoparticles
Nuclear magnetic resonance
Quaternary Ammonium Compounds - chemistry
Selective relaxation rate
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Summary:Selective relaxation rate measurements effectively proved the affinity of dexamethasone 21-phosphate disodium salt for quaternary ammonium–chitosan conjugates, their thiolated derivatives and the corresponding nanostructured aggregates. Affinity was also probed by dynamic dialysis. The release profile of dexamethasone loaded nanoparticles was defined by quantitative NMR and interrupted dialysis experiments, and mucoadhesivity of empty nanoparticles was effectively probed by selective relaxation rate measurements.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2013.12.018