Deposition and fine particle production during dynamic flow in a dry powder inhaler: A CFD approach

In this work the dynamic flow as well as the particle motion and deposition in a commercial dry powder inhaler, DPI (i.e., Turbuhaler) is described using computational fluid dynamics, CFD. The dynamic flow model presented here is an extension of a steady flow model previously described in Milenkovic...

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Bibliographic Details
Published in:International journal of pharmaceutics 2014-01, Vol.461 (1-2), p.129-136
Main Authors: Milenkovic, J., Alexopoulos, A.H., Kiparissides, C.
Format: Article
Language:English
Subjects:
Administration, Inhalation
Aerosols
CFD
Computer Simulation
Deposition
Dry powder inhaler
Dry Powder Inhalers
Dynamic
Equipment Design
Fine particle fraction
Hydrodynamics
Models, Theoretical
Particle Size
Powders
Time Factors
Turbuhaler
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Summary:In this work the dynamic flow as well as the particle motion and deposition in a commercial dry powder inhaler, DPI (i.e., Turbuhaler) is described using computational fluid dynamics, CFD. The dynamic flow model presented here is an extension of a steady flow model previously described in Milenkovic et al. (2013). The model integrates CFD simulations for dynamic flow, an Eulerian-fluid/Lagrangian-particle description of particle motion as well as a particle/wall interaction model providing the sticking efficiency of particles colliding with the DPI walls. The dynamic flow is imposed by a time varying outlet pressure and the particle injections into the DPI are assumed to occur instantaneously and follow a prescribed particle size distribution, PSD. The total particle deposition and the production of fine particles in the DPI are determined for different peak inspiratory flow rates, PIFR, flow increase rates, FIR, and particle injection times. The simulation results for particle deposition are found to agree well with available experimental data for different values of PIFR and FIR. The predicted values of fine particle fraction are in agreement with available experimental results when the mean size of the injected PSD is taken to depend on the PIFR.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2013.11.047