Efficacy of switching between tumor necrosis factor-alfa inhibitors in psoriasis: Results from the Italian Psocare Registry

• Published in: Journal of the American Academy of Dermatology 2014-02, Vol.70 (2), p.257-262.e3
• Main Authors: Piaserico, Stefano, MD, PhD, Cazzaniga, Simone, PhD Math, Chimenti, Sergio, MD, PhD, Giannetti, Alberto, MD, PhD, Maccarone, Mara, BA, Picardo, Mauro, MD, Peserico, Andrea, MD, Naldi, Luigi, MD
• Format: Article
• Language: English
• Subjects: Adalimumab; Adult; Analysis of Variance; Antibodies, Monoclonal - administration & dosage; Antibodies, Monoclonal, Humanized - administration & dosage; biologics; Cohort Studies; Confidence Intervals; Dermatology; Dose-Response Relationship, Drug; Drug Administration Schedule; efficacy; Etanercept; Female; Follow-Up Studies; Humans; Immunoglobulin G - administration & dosage; Infliximab; Italy; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; primary inefficacy; Proportional Hazards Models; psoriasis; Psoriasis - diagnosis; Psoriasis - drug therapy; Receptors, Tumor Necrosis Factor - administration & dosage; Registries; Retrospective Studies; Risk Assessment; secondary loss of efficacy; Severity of Illness Index; switching; Treatment Outcome; tumor necrosis factor-alfa inhibitors; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor Necrosis Factor-alpha - therapeutic use; Young Adult
• ISSN: 0190-9622; 1097-6787
• DOI: 10.1016/j.jaad.2013.10.019

Background Some studies have shown that switching patients from one tumor necrosis factor (TNF)-alfa inhibitor to another may be beneficial when they have an inadequate response or an adverse event. Objective We sought to assess the variables predicting the efficacy of the second TNF-alfa inhibitor in patients discontinuing the first TNF-alfa inhibitor. Methods Data from all 5423 consecutive patients starting TNF-alfa inhibitor therapy for psoriasis between September 2005 and September 2010 who were included in the Italian Psocare registry were analyzed. Results In 105 patients who switched to a second TNF-alfa inhibitor who had complete follow-up data, 75% improvement in the Psoriasis Area Severity Index score (PASI 75) was reached by 29% after 16 weeks and by 45.6% after 24 weeks. Patients who switched because of secondary loss of efficacy (loss of initial PASI 75 response) or adverse events/intolerance were more likely to reach PASI 75 than those who switched as a result of primary inefficacy (PASI 75 never achieved) (hazard ratio 2.7, 95% confidence interval 1.3-5.5 vs hazard ratio 2.0, 95% confidence interval 1.0-3.9 and 1, respectively). Limitations There was a small number of patients with complete follow-up data. Conclusion PASI 75 response in patients who switched from one anti–TNF-alfa agent to another was significantly reduced in patients who showed primary inefficacy of the first anti–TNF-alfa.