Translocation of estradiol analogs into nuclei in a cell-free system from rabbit uterus

The values of the relative translocation of structural and steric analogs of estradiol in a rabbit uterine homogenate were determined. A difference of the ligand specificity of nuclear incorporation from the specificity of the binding of estradiol analogs to the cytosol receptor was demonstrated. It...

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Bibliographic Details
Published in:Biochemistry (Easton) 1987-01, Vol.52 (1), p.92-99
Main Authors: Chernyaev, G A, Barkova, TI, Sorokina, IB, Ananchenko, S N
Format: Article
Language:English
Online Access:Get full text
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Summary:The values of the relative translocation of structural and steric analogs of estradiol in a rabbit uterine homogenate were determined. A difference of the ligand specificity of nuclear incorporation from the specificity of the binding of estradiol analogs to the cytosol receptor was demonstrated. It was established that this difference in a cell-free system arises at the level of the cytoplasmic receptor.
ISSN:0006-2960