Exercise boosts hippocampal volume by preventing early age-related gray matter loss

ABSTRACT Recently, a larger hippocampus was found in exercising mice and men. Here we studied the morphological underpinnings in wheel running mice by longitudinal magnetic resonance imaging. Voxel‐based morphometry revealed that running increases hippocampal volume by inhibiting an early age‐relate...

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Bibliographic Details
Published in:Hippocampus 2014-02, Vol.24 (2), p.131-134
Main Authors: Fuss, Johannes, Biedermann, Sarah V., Falfán-Melgoza, Claudia, Auer, Matthias K., Zheng, Lei, Steinle, Jörg, Hörner, Felix, Sartorius, Alexander, Ende, Gabriele, Weber-Fahr, Wolfgang, Gass, Peter
Format: Article
Language:English
Subjects:
aging
Aging - pathology
Animals
brain matter
Cranial Irradiation - adverse effects
hippocampus
Hippocampus - pathology
Hippocampus - radiation effects
Imaging, Three-Dimensional
Longitudinal Studies
Magnetic Resonance Imaging
Male
Mice
Mice, Inbred C57BL
Physical Conditioning, Animal - physiology
Running
sports
wheel running
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Summary:ABSTRACT Recently, a larger hippocampus was found in exercising mice and men. Here we studied the morphological underpinnings in wheel running mice by longitudinal magnetic resonance imaging. Voxel‐based morphometry revealed that running increases hippocampal volume by inhibiting an early age‐related gray matter loss. Disruption of neurogenesis‐related neuroplasticity by focalized irradiation is sufficient to block positive effects of exercise on macroscopic brain morphology. © 2013 Wiley Periodicals, Inc.
ISSN:1050-9631
1098-1063
DOI:10.1002/hipo.22227