Leptin levels and risk of type 2 diabetes: gender‐specific meta‐analysis

This meta‐analysis aimed to assess the gender‐specific differences in the relationship between circulating leptin levels and risk of type 2 diabetes. Published prospective studies that reported the association of leptin levels with risk of type 2 diabetes for a certain gender or those that reported...

Full description

Saved in:
Bibliographic Details
Published in:Obesity reviews 2014-02, Vol.15 (2), p.134-142
Main Authors: Chen, G.‐C, Qin, L.‐Q, Ye, J.‐K
Format: Article
Language:English
Subjects:
Adipocytokines
Biomarkers - blood
confidence interval
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - prevention & control
Female
gender differences
Humans
least squares
leptin
Leptin - blood
Male
men
meta-analysis
noninsulin-dependent diabetes mellitus
Obesity - blood
Obesity - epidemiology
Prospective Studies
risk
Risk Factors
Sex Factors
type 2 diabetes
women
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This meta‐analysis aimed to assess the gender‐specific differences in the relationship between circulating leptin levels and risk of type 2 diabetes. Published prospective studies that reported the association of leptin levels with risk of type 2 diabetes for a certain gender or those that reported gender‐specific associations were considered. Dose‐response relationships were assessed by the generalized least squares trend estimation and summary relative risks (RRs) with 95% confidence interval (CI) were computed with the random‐effects model. Stratified and sensitivity analyses were also performed to investigate potential sources of heterogeneity. Overall, 11 prospective studies were identified. The summary RR for an increment in leptin levels of 1‐log ng mL⁻¹ was 1.37 (95% CI, 1.13–1.66) for men and 0.96 (95% CI, 0.90–1.03) for women. The differences between genders were statistically significant (P for interaction = 0.006). Subgroup and sensitivity analyses generally confirmed the robustness of these findings. Furthermore, the increased risk in men appeared non‐linear, with a tendency to plateau at high levels (P for non‐linearity = 0.03). Little evidence of publication bias was found. Collectively, higher leptin levels were found to be associated with elevated risk of type 2 diabetes in men but not in women.
ISSN:1467-7881
1467-789X
DOI:10.1111/obr.12088